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Human HLA-Expressing Mouse Strains
Reagent DescriptionsTwo reagents are available:
HLA-A2.1: This transgenic mouse strain was constructed by microinjection of the 7kb EcoRI fragment containing the full-length HLA-A2.1 gene into fertilized eggs from C57BL/6 mice. The strain expresses human class I MHC Ag HLA-A2.1 on cells from the spleen, bone marrow and thymus. A full description can...
Published: 3/7/2012
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Inventor(s): Victor Engelhard
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Category(s): Mouse Strains
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TASK1 and TASK3 Knockout Mouse Strains
Reagent DescriptionsFive reagents are available:
Task1flox: In this strain, the gene for TASK-1 (K2P3.1, Kcnk3) has been flanked by loxP sites in order to support Cre-mediated excision. Targeting constructs were generated from restriction fragments of genomic DNA surrounding exon II of each TASK-1 derived from a BAC construct. Flanking loxP sites and...
Published: 3/7/2012
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Inventor(s): Douglas Bayliss, Edmund Talley
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Category(s): Mouse Strains
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Sno Knockout Mouse Strain
Reagent DescriptionThese mutant mice may be useful in studies of T cell activation, T cell receptor stimulation and TGF-beta signaling. A targeting vector was designed to replace exon 1 of the endogenous gene with a lacZ gene (with a nuclear localization signal) and a loxP-flanked PGK-neo cassette. This construct was microinjected into (129X1/SvJ x...
Published: 3/7/2012
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Inventor(s): Sonia Pearson-White
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Category(s): Mouse Strains
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GnRH Neuron GFP-Expressing Mouse Strain
Reagent DescriptionThis transgenic mouse line expresses the reporter green fluorescent protein (GFP) under the control of the mouse gonadotrophin-releasing hormone (GnRH) promoter. This allows the identification of GnRH neurons in the brain without further processing. Founder strain CBB6/F1 was partially backcrossed onto C57BL6/J so that current mice...
Published: 3/7/2012
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Inventor(s): Suzanne Moenter
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Category(s): Mouse Strains
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Circadian Rhythm-Induced Luciferase Expression in a Rat Strain
Reagent DescriptionThis rat strain is useful for studying the organization of the mammalian circadian system. In this transgenic rat line, luciferase is rhythmically expressed under the control of the mouse Per1 promoter. Cells isolated from the suprachiasmatic nuclei (SCN) continue rhythmical light emission for up to 32 days in vitro. A mouse Per1...
Published: 3/7/2012
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Inventor(s): Michael Menaker, Shin Yamazaki
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Category(s): Mouse Strains
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Crohn's Disease Mouse Model
Reagent DescriptionSAMP1/YitFcs (also called SAMP1/YitFc or SAMP1/Fc) mice develop a spontaneous ileitis that is similar in many features to human Crohn’s disease. Development of ileitis is accelerated by the presence of luminal bacteria and is characterized by discontinuous segmental inflammation involving the ileum while sparing the proximal...
Published: 3/7/2012
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Category(s): Mouse Strains
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Diabetes-Resistant Mouse Strains
Reagent DescriptionThese mouse strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are useful for identifying candidate genes within the Idd4 subloci. Strain 008053 and 008061 are known in the literature as DR3 and DR4, respectively.Strains...
Published: 3/7/2012
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Inventor(s): Marcia Mcduffie
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Category(s): Mouse Strains
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SCID Mouse Model Expressing Human HLA-A2.1
Reagent DescriptionNOD.CB17-PrkdcSCID (SCID mouse) was crossed once with NOD.B6-TgN(HLA-A2.1)1Enge/Dvs, and the doubly heterozygous offspring were backcrossed once to NOD.CB17-PrkdcSCID, to make the strain homozygous for Prkdc SCID, then sibling-mated to fix the strain homozygous for TgN(HLA-A2.1)1Enge. A full description can be found at the Jackson...
Published: 3/7/2012
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Inventor(s): Victor Engelhard
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Category(s): Mouse Strains
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Type 1 Diabetes Mouse Model Expressing Human HLA-A2.1
Reagent DescriptionThis model is useful for studying the role of MHC class I molecules in Type 1 Diabetes. The transgenic allele HLA-A2.1 from C57BL/6-Tg(HLA-A2.1)1Enge/J (stock# 3088) was backcrossed 10 generations to NOD/Lt prior to making the homozygote. Homozygous mice carrying the (HLA-A2.1)1Enge transgene ubiquitously express significant quantities...
Published: 3/7/2012
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Inventor(s): Victor Engelhard
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Category(s): Mouse Strains
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Connexin 43 (CX43) flox Mouse Strain
Reagent DescriptionMice homozygous for this CX43flox conditional allele are viable and fertile, with loxP sites flanking exon 2 of the targeted gene. Presence of the loxP sites has no reported effect on expression of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have exon 2 deleted in the Cre-expressing...
Published: 3/7/2012
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Inventor(s): Brian Duling, Yongbo Liao
Keywords(s):
Category(s): Mouse Strains
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