Description:
Reagent Description
Mice homozygous for this CX43flox conditional allele are viable and fertile, with loxP sites flanking exon 2 of the targeted gene. Presence of the loxP sites has no reported effect on expression of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have exon 2 deleted in the Cre-expressing tissue(s). These CX43flox mutant mice may be useful in generating conditional mutations for studying the role of connexin and gap junctions in various tissues and systems, including the cardiovascular system.
A full description can be found at the Jackson Laboratory, where this strain is sold as stock number 008039. Use of this strain by companies or for-profit entities requires a license from the U.Va. Patent Foundation.
Strain Name
B6.129S7-Gja1tm1Dlg/J
References
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9989-94. (Available online.)
