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Diabetes-Resistant Mouse Strains

Description:

Reagent Description
These mouse strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are useful for identifying candidate genes within the Idd4 subloci. 

Strain 008053 and 008061 are known in the literature as DR3 and DR4, respectively.

Strains 008062, 008063 and 008064 are reported to be both diabetes- and lupus-resistant.

A full description of the strains can be found at the Jackson Laboratory website using the links below. Use of this strain by companies or for-profit entities requires a license from the U.Va. Patent Foundation.

JAX Number
Strain Name
008053
NOD.L-(D11Mit314-D11Mit42)/McdfJ
008054
NOD.L-(D11Mit314-D11Mit339)/McdfJ
008055
NOD.L-(D11Mit314-Csf2)/McdfJ
008056
NOD.L-(Csf2-D11Mit339)/McdfJ
008057 NOD.L-(D11Mit314-D11Mit33)/McdfJ
008058 NOD.L-(D11Mit314-D11Mit339)(D11Mit364-D11Mit168)/McdfJ
008059 NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ
008060 NOD.L-(D11Mit314-D11Mit339)(D11Mit132-D11Mit42)/McdfJ
008061 NOD.L-(D7Mit253-D7Mit242)/McdfJ
008062 NOD-Chr1 NZM2328/McdfJ
008063 NOD-Chr17 NZM2328/McdfJ
008064 NOD-Chr4 NZM2328/McdfJ

References
Clin Immunol. 2000 Aug;96(2):119-30. (Available online.)
J Immunol. 2005 Oct 1;175(7):4561-5. (Available online.)
Biochem Biophys Res Commun. 2007 May 11;356(3):655-61. (Available online.)

Patent Information:
Category(s):
Mouse Strains
For Information, Contact:
Stephanie Miller
Licensing Associate
UVA
stephanie@uvapf.org
Inventors:
Marcia McDuffie
Keywords:
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