Description:
Reagent Description
SAMP1/YitFcs (also called SAMP1/YitFc or SAMP1/Fc) mice develop a spontaneous ileitis that is similar in many features to human Crohn’s disease. Development of ileitis is accelerated by the presence of luminal bacteria and is characterized by discontinuous segmental inflammation involving the ileum while sparing the proximal small intestine and colon. The histopathologic features of SAMP1/Fc ileitis include transmural inflammation, crypt abscesses and epithelial changes such as loss of villi, crypt elongation and crypt branching.
SAMP1/Fc mice were originally distinguished from the strain from which they were derived (SAMP1/Yit) by spontaneous onset of ileum inflammation by 10 weeks of age at nearly 100 percent penetrance and the emergence of a perianal fistulizing disease not reported in the parental strain. Other distinguishing characteristics of the SAMP1/Fc substrain include incidence of skin lesions inversely correlated with the occurrence of intestinal inflammation, chronic ileitis with prominent muscular hypertrophy and focal collagen deposition in inflamed segments, activation of mesenteric lymph node lymphocytes coincident with ileitis progression, and high interferon-γ production preceding ileitis onset.
A full description can be found at the Jackson Laboratory, where this strain is sold as stock number 009355. Use of this strain by companies or for-profit entities requires a license from the U.Va. Patent Foundation.
References
Gastroenterology. 2003 Aug;125(2):477-90. (Available online.)
