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Search Results - victor engelhard

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Human HLA-Expressing Mouse Strains
Reagent DescriptionsTwo reagents are available: HLA-A2.1: This transgenic mouse strain was constructed by microinjection of the 7kb EcoRI fragment containing the full-length HLA-A2.1 gene into fertilized eggs from C57BL/6 mice. The strain expresses human class I MHC Ag HLA-A2.1 on cells from the spleen, bone marrow and thymus. A full description c...
Published: 3/7/2012   |   Inventor(s): Victor Engelhard
Keywords(s):  
Category(s): Mouse Strains
SCID Mouse Model Expressing Human HLA-A2.1
Reagent DescriptionNOD.CB17-PrkdcSCID (SCID mouse) was crossed once with NOD.B6-TgN(HLA-A2.1)1Enge/Dvs, and the doubly heterozygous offspring were backcrossed once to NOD.CB17-PrkdcSCID, to make the strain homozygous for Prkdc SCID, then sibling-mated to fix the strain homozygous for TgN(HLA-A2.1)1Enge. A full description can be found at the Jackso...
Published: 3/7/2012   |   Inventor(s): Victor Engelhard
Keywords(s):  
Category(s): Mouse Strains
Type 1 Diabetes Mouse Model Expressing Human HLA-A2.1
Reagent DescriptionThis model is useful for studying the role of MHC class I molecules in Type 1 Diabetes. The transgenic allele HLA-A2.1 from C57BL/6-Tg(HLA-A2.1)1Enge/J (stock# 3088) was backcrossed 10 generations to NOD/Lt prior to making the homozygote. Homozygous mice carrying the (HLA-A2.1)1Enge transgene ubiquitously express significant quan...
Published: 3/7/2012   |   Inventor(s): Victor Engelhard
Keywords(s):  
Category(s): Mouse Strains
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