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Novel Dye Improves Breast Cancer Imaging, Detection
Executive Summary
Radiology researchers at the University of Virginia and Cedars-Sinai Medical Center have developed novel heptamethine dyes that possess both nuclear and near-infrared imaging capabilities for imaging, targeting and detecting tumors. While this imaging technique is being specifically developed for invasive breast cancer, there are future...
Published: 2/6/2013
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Inventor(s): Dongfeng Pan, Leland Chung
Keywords(s): Cancer, Imaging
Category(s): Diagnostics & Assays
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Human C3 (Complement Protein) Antibodies
Production and Reactivity These mouse IgG1 monoclonal antibodies were generated against human C3 and recognize mouse and human homologs of C3 and its breakdown products C3b and iC3b.Clone Numbers10C76C9-D2-A6ApplicationsFC, ELISAReferencesMol Immunol. 2007 Jan;44(4):377-88.
Published: 3/8/2012
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Inventor(s): Ronald Taylor, William Sutherland
Keywords(s): Antibody
Category(s): Antibodies
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Dynein Light Chain 1/3 (DYNLT1/3) Antibodies
Production and Reactivity These mouse IgG1 monoclonal antibodies recognize rat and human homologs of both Dynein Light Chain 1 (DYNLT1) and Dynein Light Chain 3 (DNYLT3).Clone Numbers10F6-D1-D96C4-C12-F8ApplicationsIP, IFReferencesJ Biol Chem. 2007 Dec 21;282(51):36871-8.
Published: 3/8/2012
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Inventor(s): Kevin Pfister
Keywords(s): Antibody
Category(s): Antibodies
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Nuclear Transport Factor 2 (NTF2) Antibodies
Production and ReactivityThese mouse monoclonal antibodies were generated against human NTF2.
Clone Number
Isotype
Antigen
Epitope
Reactivity
4F5
IgG2b
Full length recombinant NTF2
C-terminus
Human, Xenopus
5A3
IgG2a
Full length recombinant NTF2
Not defined
Human, Xenopus
5E8
IgG1
NTF2 peptide (amino acids 1-14)
N-terminus
Human
ApplicationsWB,...
Published: 3/8/2012
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Inventor(s): Bryce Paschal
Keywords(s): Antibody
Category(s): Antibodies
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Multiplex PCR Detection of Viral, Parasite and Bacterial Pathogens
Executive SummaryInfectious disease researchers at the University of Virginia have developed quantitative multiplex RT-PCR assays for the major viral, bacterial, protozoan and helminthes causes of infectious gastroenteritis. BackgroundInfectious gastroenteritis, or the “stomach flu,” results in acute diarrhea, vomiting and abdominal pain....
Published: 3/8/2012
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Inventor(s): Eric Houpt, Jie Liu
Keywords(s): Diagnostics
Category(s): Diagnostics & Assays
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SMARCAL1 (ATPase A) Antibodies
Production and ReactivityThese mouse monoclonal antibodies were generated against bovine SMARCAL1 and recognize the species indicated below in addition to the bovine homolog. No antibody clone neutralizes DNA-dependent ATP hydrolysis. The relative reactivity to human SMARCAL1 by WB is 5A12 > 4B10 > 10H7 > 5G4 > 6E12 > 2D1.
Clone
Isotype
ELISA
WB
IF
IP
Human
Mouse
2A3
IgG1
Y
Y
Y
5G4
IgG1
Y
Y
Y
Y
Y
1H10
IgG2a
Y
Y
Y
5A12
IgG1
Y
Y
Y
Y
Y
3B2
IgG1
Y
Y
Y
7B1
IgG1
Y
Y
Y
10H7
IgG1
Y
Y
Y
Y
Y
10E8
IgG1
Y
Y
Y
Y
4B10
IgG1
Y
Y
Y
Y
Y
6E12
IgG1
Y
Poor
Y
Y
Y
Y
2D1
IgG1
Poor
Y
Y
Y
6E2
Mixed*
Y
Y
4H11
Mixed*
Y
Y
*IgG1,...
Published: 3/8/2012
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Inventor(s): Joel Hockensmith
Keywords(s): Antibody
Category(s): Antibodies
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Bordetella Pertussis Adenylate Cyclase (AC) Toxin Antibody
Production and ReactivityThese mouse monoclonal antibodies have been generated against the purified B. pertussis AC toxin and also recognize other RTX family bacterial toxins (2F5 and 9D4 only).
Clone Number
Isotype
Epitope
3D1
IgG1
Distal portion of catalytic domain (amino acids 373–399)
2F5
IgG1
Glycine and aspartate-rich nonapeptide...
Published: 3/8/2012
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Inventor(s): Erik Hewlett, Mary Gray
Keywords(s): Antibody
Category(s): Antibodies
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Method for Efficient Mass-Production of Surface Textures
Courtesy of Gupta laboratory
Microscopic view of a laser
micro-textured surface.
BackgroundSurface texturing has become an important tool
for enhancing surface properties, particularly in fields such as solar and wind
energy, aeronautics and medicine. Surface texture is typically generated by
chemical etching, a costly and...
Published: 3/22/2012
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Inventor(s): Mool Gupta, Barada Nayak, Paul Caffrey
Keywords(s):
Category(s): Novel Materials & Processes
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MBP/Beta-Tubulin Fusion Proteins
DescriptionThe isotype-defining domain (C-terminal 16 amino acids) of each class of human beta-tubulin was fused to Maltose Binding Protein (MBP) and expressed in bacteria. The fusion proteins* are expressed in high amounts, can be purified by maltose chromatography and are very soluble in aqueous buffers. The proteins can be used as a standard in quantitative...
Published: 3/7/2012
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Inventor(s): Tony Frankfurter, Anthony Spano
Keywords(s):
Category(s): Recombinant Proteins and Peptides
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Nidogen/Enactin Antibodies
Production and Reactivity: Rat monoclonal antibodies generated against mouse nidogen and recognize mouse and human homologs. Blocks nidogen binding to laminin. Clone number Isotype Epitope JF1 IgG2a G1/link region JF2 IgG2a G3 region JF3 IgG2a G1/link region JF4 ...
Published: 3/8/2012
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Inventor(s): Jay Fox, Rupert Timpl
Keywords(s): Antibody
Category(s): Antibodies
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