Description:
Reagent Description
These mouse strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are useful for identifying candidate genes within the Idd4 subloci.
Strain 008053 and 008061 are known in the literature as DR3 and DR4, respectively.
Strains 008062, 008063 and 008064 are reported to be both diabetes- and lupus-resistant.
A full description of the strains can be found at the Jackson Laboratory website using the links below. Use of this strain by companies or for-profit entities requires a license from the U.Va. Patent Foundation.
JAX Number
|
Strain Name
|
008053
|
NOD.L-(D11Mit314-D11Mit42)/McdfJ |
008054
|
NOD.L-(D11Mit314-D11Mit339)/McdfJ |
008055
|
NOD.L-(D11Mit314-Csf2)/McdfJ |
008056
|
NOD.L-(Csf2-D11Mit339)/McdfJ |
| 008057 |
NOD.L-(D11Mit314-D11Mit33)/McdfJ |
| 008058 |
NOD.L-(D11Mit314-D11Mit339)(D11Mit364-D11Mit168)/McdfJ |
| 008059 |
NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ |
| 008060 |
NOD.L-(D11Mit314-D11Mit339)(D11Mit132-D11Mit42)/McdfJ |
| 008061 |
NOD.L-(D7Mit253-D7Mit242)/McdfJ |
| 008062 |
NOD-Chr1 NZM2328/McdfJ |
| 008063 |
NOD-Chr17 NZM2328/McdfJ |
| 008064 |
NOD-Chr4 NZM2328/McdfJ |
References
Clin Immunol. 2000 Aug;96(2):119-30. (Available online.)
J Immunol. 2005 Oct 1;175(7):4561-5. (Available online.)
Biochem Biophys Res Commun. 2007 May 11;356(3):655-61. (Available online.)
