<?xml version="1.0" encoding="utf-8"?><rss version="2.0"><channel><title>Latest technologies from UVA</title><link>http://uva.technologypublisher.com</link><description>Be the first to know about the latest inventions and technologies available from UVA</description><language>en-US</language><pubDate>Mon, 20 Apr 2026 15:34:47 GMT</pubDate><lastBuildDate>Wed, 06 Feb 2013 10:54:44 GMT</lastBuildDate><docs>http://blogs.law.harvard.edu/tech/rss</docs><webMaster>estabrook@virginia.edu</webMaster><copyright>Copyright 2026, UVA</copyright><item><title>Novel Dye Improves Breast Cancer Imaging, Detection</title><caseId>M-PAN-DUAL</caseId><link>http://uva.technologypublisher.com/technology/11835</link><description><![CDATA[
Executive Summary
Radiology researchers at the University of Virginia and Cedars-Sinai Medical Center have developed novel heptamethine dyes that possess both nuclear and near-infrared imaging capabilities for imaging, targeting and detecting tumors. While this imaging technique is being specifically developed for invasive breast cancer, there are future possibilities of applying it to prostate and other cancers.
&nbsp;
Background
Breast cancer remains one of the most prevalent cancer diseases in women of developed countries The American Cancer Society (ACS) estimates that 226,870 new cases o...]]></description><pubDate>Wed, 06 Feb 2013 10:54:44 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/11835</guid></item><item><title>Human C3 (Complement Protein) Antibodies</title><caseId>M-TAYLOR-10C7,6C9</caseId><link>http://uva.technologypublisher.com/technology/9083</link><description>Production and Reactivity These mouse IgG1 monoclonal antibodies were generated against human C3 and recognize mouse and human homologs of C3 and its breakdown products C3b and iC3b.Clone Numbers10C76C9-D2-A6ApplicationsFC, ELISAReferencesMol Immunol. 2007 Jan;44(4):377-88.</description><pubDate>Wed, 07 Mar 2012 09:34:24 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9083</guid></item><item><title>Dynein Light Chain 1/3 (DYNLT1/3) Antibodies</title><caseId>M-PFISTER-DYNR2,3</caseId><link>http://uva.technologypublisher.com/technology/9082</link><description>Production and Reactivity These mouse IgG1 monoclonal antibodies recognize rat and human homologs of both Dynein Light Chain 1 (DYNLT1) and Dynein Light Chain 3 (DNYLT3).Clone Numbers10F6-D1-D96C4-C12-F8ApplicationsIP, IFReferencesJ Biol Chem. 2007 Dec 21;282(51):36871-8.</description><pubDate>Wed, 07 Mar 2012 09:34:23 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9082</guid></item><item><title>Nuclear Transport Factor 2 (NTF2) Antibodies</title><caseId>M-PASCHAL-ABNTF2</caseId><link>http://uva.technologypublisher.com/technology/9081</link><description><![CDATA[Production and ReactivityThese mouse monoclonal antibodies were generated against human NTF2.



Clone Number
Isotype
Antigen
Epitope
Reactivity


4F5
IgG2b
Full length recombinant NTF2
C-terminus
Human, Xenopus


5A3
IgG2a
Full length recombinant NTF2
Not defined
Human, Xenopus


5E8
IgG1
NTF2 peptide (amino acids 1-14)
N-terminus
Human



ApplicationsWB, IF
ReferencesMol Biol Cell. 2000 Feb;11(2):703-19. (Available online.)
&nbsp;]]></description><pubDate>Wed, 07 Mar 2012 09:34:22 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9081</guid></item><item><title>Multiplex PCR Detection of Viral, Parasite and Bacterial Pathogens</title><caseId>M-HOUPT-PATHOGENS</caseId><link>http://uva.technologypublisher.com/technology/9080</link><description><![CDATA[Executive SummaryInfectious disease researchers at the University of Virginia have developed quantitative multiplex RT-PCR assays for the major viral, bacterial, protozoan and helminthes causes of infectious gastroenteritis.&nbsp;&nbsp; BackgroundInfectious gastroenteritis, or the &ldquo;stomach flu,&rdquo; results in acute diarrhea, vomiting and abdominal pain. In the United States, an estimated 211&ndash;375 million episodes of diarrheal illness occur each year, resulting in 73 million physician consultations, 1.8 million hospitalizations and 3,100 deaths. The economic costs of infectious di...]]></description><pubDate>Wed, 07 Mar 2012 09:34:20 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9080</guid></item><item><title>SMARCAL1 (ATPase A) Antibodies</title><caseId>M-HOCKENSMITH</caseId><link>http://uva.technologypublisher.com/technology/9079</link><description><![CDATA[Production and ReactivityThese mouse monoclonal antibodies were generated against bovine SMARCAL1 and recognize the species indicated below in addition to the bovine homolog. No antibody clone neutralizes DNA-dependent ATP hydrolysis. The relative reactivity to human SMARCAL1 by WB is 5A12 &gt; 4B10 &gt; 10H7 &gt; 5G4 &gt; 6E12 &gt; 2D1.  



Clone
Isotype
ELISA
WB
IF
IP
Human
Mouse


2A3
IgG1
Y
Y

Y

&nbsp;


5G4
IgG1
Y
Y

Y
Y
Y


1H10
IgG2a
Y
Y

Y

&nbsp;


5A12
IgG1
Y
Y

Y
Y
Y


3B2
IgG1
Y
Y

Y

&nbsp;


7B1
IgG1
Y
Y

Y

&nbsp;


10H7
IgG1
Y
Y

Y
Y
Y


10E8
IgG1
Y
Y

Y
Y
&nbsp;


4B10
IgG1
...]]></description><pubDate>Wed, 07 Mar 2012 09:34:18 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9079</guid></item><item><title>Bordetella Pertussis Adenylate Cyclase (AC) Toxin Antibody</title><caseId>M-HEWLETT-2F5,3D1,9D</caseId><link>http://uva.technologypublisher.com/technology/9078</link><description><![CDATA[Production and ReactivityThese mouse monoclonal antibodies have been generated against the purified B. pertussis AC toxin and also recognize other RTX family bacterial toxins (2F5 and 9D4 only). 



Clone Number
Isotype
Epitope


3D1
IgG1
Distal portion of catalytic domain (amino acids 373&ndash;399)


2F5
IgG1
Glycine and aspartate-rich nonapeptide repeat region (amino acids 1156&ndash;1489)


9D4
IgG2a
Glycine and aspartate-rich nonapeptide repeat region (amino acids 1156&ndash;1489)




ApplicationsWB, IP
ReferencesInfect Immun. 1999 May;67(5):2090-5.]]></description><pubDate>Wed, 07 Mar 2012 09:34:16 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9078</guid></item><item><title>Method for Efficient Mass-Production of Surface Textures</title><caseId>M-GUPTA-SURFACE</caseId><link>http://uva.technologypublisher.com/technology/9076</link><description>
Courtesy of Gupta laboratory



  
  
  
  
    Microscopic view of a laser 
      micro-textured surface.
BackgroundSurface texturing has become an important tool 
for enhancing surface properties, particularly in fields such as solar and wind 
energy, aeronautics and medicine. Surface texture is typically generated by 
chemical etching, a costly and time-consuming process that is known not to be 
very effective for polycrystalline and thin film semiconductors. 
Invention DescriptionResearchers at the University 
of Virginia have developed novel methods for generating micro- and nano-texture...</description><pubDate>Wed, 07 Mar 2012 09:34:12 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9076</guid></item><item><title>MBP/Beta-Tubulin Fusion Proteins</title><caseId>M-FRANKFURTER-MALT</caseId><link>http://uva.technologypublisher.com/technology/9075</link><description>DescriptionThe isotype-defining domain (C-terminal 16 amino acids) of each class of human beta-tubulin was fused to Maltose Binding Protein (MBP) and expressed in bacteria. The fusion proteins* are expressed in high amounts, can be purified by maltose chromatography and are very soluble in aqueous buffers. The proteins can be used as a standard in quantitative western blotting, dot blotting and ELISA.ReferencesMethods Cell Biol. 2010;95:33-46. (Available online.) *The fusion proteins are expressed from a modified pMal-C2 vector. Commercial use of the fusion proteins may require a license from ...</description><pubDate>Wed, 07 Mar 2012 09:34:10 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9075</guid></item><item><title>Nidogen/Enactin Antibodies</title><caseId>M-FOX-NIDOGEN</caseId><link>http://uva.technologypublisher.com/technology/9074</link><description><![CDATA[Production and Reactivity:&nbsp; Rat monoclonal antibodies generated against mouse nidogen and recognize mouse and human homologs. Blocks nidogen binding to laminin. Clone number&nbsp;&nbsp;&nbsp; Isotype&nbsp;&nbsp; &nbsp; &nbsp;&nbsp; Epitope&nbsp;&nbsp;&nbsp; JF1&nbsp;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;&nbsp;&nbsp; IgG2a&nbsp;&nbsp;&nbsp;&nbsp; G1/link region&nbsp;&nbsp;&nbsp; JF2&nbsp;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;&nbsp;&nbsp; IgG2a&nbsp; &nbsp;&nbsp; G3 region&nbsp;&nbsp;&nbsp; JF3&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&n...]]></description><pubDate>Wed, 07 Mar 2012 09:34:08 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9074</guid></item><item><title>Human HLA-Expressing Mouse Strains</title><caseId>M-ENGELHARD-MOUSE</caseId><link>http://uva.technologypublisher.com/technology/9073</link><description>Reagent DescriptionsTwo reagents are available:

HLA-A2.1: This transgenic mouse strain was constructed by microinjection of the 7kb EcoRI fragment containing the full-length HLA-A2.1 gene into fertilized eggs from C57BL/6 mice. The strain expresses human class I MHC Ag HLA-A2.1 on cells from the spleen, bone marrow and thymus. A full description can be found at the Jackson Laboratory, where this strain is sold as stock number 003475. Use of this strain by companies or for-profit entities requires a license from the U.Va. Patent Foundation.


HLA-AAD: This strain was constructed by microinject...</description><pubDate>Wed, 07 Mar 2012 09:34:08 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9073</guid></item><item><title>TASK1 and TASK3 Knockout Mouse Strains</title><caseId>M-BAYLISS-VARIOUS</caseId><link>http://uva.technologypublisher.com/technology/9072</link><description>Reagent DescriptionsFive reagents are available:

Task1flox: In this strain, the gene for TASK-1 (K2P3.1, Kcnk3) has been flanked by loxP sites in order to support Cre-mediated excision. Targeting constructs were generated from restriction fragments of genomic DNA surrounding exon II of each TASK-1 derived from a BAC construct. Flanking loxP sites and a neomycin resistance cassette were inserted into the gene fragments, and the resulting construct was transfected into embryonic stem cells for homologous recombination. Chimeric founders were obtained following blastocyst injection with ES cells...</description><pubDate>Wed, 07 Mar 2012 09:34:07 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9072</guid></item><item><title>Multimodality Imaging Probe for Protein Critical to the Development of Arterial Obstructions, LOX-1</title><caseId>M-MEYER-LOX1 (REAGE)</caseId><link>http://uva.technologypublisher.com/technology/9069</link><description>Executive SummaryThe invention is a multimodality imaging probe for detecting the oxidized LDL receptor, LOX-1. The researchers have successfully demonstrated LOX-1 staining using SPECT/CT, MRI and fluorescent imaging.BackgroundLOX-1 is a type II membrane protein with a short N-terminal cytoplasmic domain and a long C-terminal extracellular domain that is the receptor for oxidized LDL. It is expressed in endothelial cells, proliferated smooth muscle cells and macrophages. It has been shown that LOX-1 plays a critical role in atherogenesis, the development of plaques within arteries. These plaq...</description><pubDate>Wed, 07 Mar 2012 09:34:04 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9069</guid></item><item><title>Novel Atherosclerotic Plaque Detection/Assessment Technique for the Treatment of Heart Disease</title><caseId>M-MEYER-LOX-1</caseId><link>http://uva.technologypublisher.com/technology/9068</link><description>


  
  
  
  
    Courtesy Meyer 
  Laboratory


  
  
  
  
    SPECT/CT imaging (A), phosphor 
      imaging (B) and Sudan IV staining (C). All mice injected with LOX-1 probe 
      had hotspots in the aortic arch (sagittal, coronal and transversal 
      plane).
Executive SummaryUniversity of Virginia researchers have 
developed a novel, non-invasive imaging technique for the detection and 
assessment of atherosclerotic plaques. This technique detects atherosclerotic 
lesions and can identify which are rupture-prone, vulnerable plaques, leading to 
an accurate assessment of heart disease a...</description><pubDate>Wed, 07 Mar 2012 09:34:04 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9068</guid></item><item><title>Novel Compounds for the Treatment of Diarrheal Diseases</title><caseId>M-HOFFMAN-CYANO-DIA</caseId><link>http://uva.technologypublisher.com/technology/9067</link><description><![CDATA[Executive SummaryUniversity of Virginia researchers have created novel derivative compounds of FDA-approved drug Nitazoxanide (NTZ) that show reduced toxicity, improved bioavailability and greater efficacy against a range of organisms that cause diarrheal diseases.&nbsp; BackgroundDiarrheal diseases are especially common in children, immuno-compromised individuals, people living in developing nations, international travelers, patients undergoing long-term hospitalization and nursing home residents. Infectious diarrheal diseases are the second-highest global cause of morbidity and mortality. Co...]]></description><pubDate>Wed, 07 Mar 2012 09:34:03 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9067</guid></item><item><title>Novel Compounds for Prevention and Treatment of Bacterial Infections and Biofilms</title><caseId>M-HOFFMAN-CYANO-BAC</caseId><link>http://uva.technologypublisher.com/technology/9066</link><description>Executive SummaryUniversity of Virginia researchers have created novel derivative compounds of FDA-approved drug Nitazoxanide (NTZ) that show reduced toxicity, improved bioavailability and greater efficacy against bacterial infections and biofilms.BackgroundOpportunistic hospital-acquired pathogens, including S. epidermidis and S. aureus, are the leading cause of catheter and in-dwelling device-associated infections. Their ability to cause disease depends on adherence to polymer surfaces, where they form biofilms. These infections lead to increased morbidity, mortality, lengths of hospitalizat...</description><pubDate>Wed, 07 Mar 2012 09:34:02 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9066</guid></item><item><title>Method and Device for Maximizing Memory System Bandwidth by Accessing Data in a Dynamically Determined Order</title><caseId>M-WULF-MEMORY</caseId><link>http://uva.technologypublisher.com/technology/9065</link><description><![CDATA[Microprocessor performance has increased by 50&minus;100 percent per year in the last decade, while DRAM performance has risen only 10&minus;15 percent per year. Memory bandwidth, therefore, is rapidly becoming the performance bottleneck in the application of high-performance microprocessors to vector-like algorithms.This invention is a method of rapid data access using a data processor for processing information with memory for information storage in conjunction with a memory control device that controls the access of stored information from memory. The memory control device is provided with ...]]></description><pubDate>Wed, 07 Mar 2012 09:34:01 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9065</guid></item><item><title>FLUX SHUTTLE RAM:  High-Density Magnetic Random Access Memory</title><caseId>M-WOLF-SHUTTLE</caseId><link>http://uva.technologypublisher.com/technology/9064</link><description>Executive SummaryThe invention is a novel method for achieving magnetic random access memory (MRAM) that enables higher memory densities and faster write speeds while lowering the energy consumed when writing to memory.BackgroundAlthough non-volatile computer memory has the ability to store information even when not powered, it is typically disadvantaged by cost or performance when compared to volatile types of memory. MRAM, a type of non-volatile memory, is expected to overcome these disadvantages and potentially displace volatile memory technologies, enabling more energy-efficient computers ...</description><pubDate>Wed, 07 Mar 2012 09:34:00 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9064</guid></item><item><title>MAP Kinase 2 Antibody</title><caseId>M-WEBER-MW01</caseId><link>http://uva.technologypublisher.com/technology/9062</link><description>Production and Reactivity This mouse IgG2a monoclonal antibody was generated against HPLC purified murine recombinant MAP kinase and recognizes avian, human, mouse and rat homologs.Clone Number1B9-B9-E4ApplicationsWB, IP</description><pubDate>Wed, 07 Mar 2012 09:33:58 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9062</guid></item><item><title>Integrative Technique for Improved Signal-to-Noise Ratio in Medical Imaging</title><caseId>M-WALKER-SCATTER</caseId><link>http://uva.technologypublisher.com/technology/9061</link><description><![CDATA[Executive SummaryResearchers led by the University of Virginia&rsquo;s William F. Walker, Ph.D., have developed an angular imaging system that improves the quality and diagnostic potential of medical imaging techniques. This novel technology uses translating apertures to acquire medical images with an improved signal-to-noise ratio (SNR) and, unlike conventional ultrasound systems, acquires data at a number of angles of interrogation.BackgroundIn medical imaging, two types of wave energy are produced as the incident wave scatters from tissue structures: backscatter and angular scatter. As conv...]]></description><pubDate>Wed, 07 Mar 2012 09:33:58 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9061</guid></item><item><title>A Novel Spline-Based Algorithm for Multidimensional Displacement and Strain Estimation</title><caseId>M-WALKER-MUSE</caseId><link>http://uva.technologypublisher.com/technology/9059</link><description>Researchers at the University of Virginia have developed a novel motion estimation algorithm based on a continuous representation of discrete-sample images, with accuracy better than one 100th of a sample. A novel strategy is employed to reduce computational cost and minimize memory requirements. In addition to rigid body motion, local stretching/compression and shear, or other complex deformations, can be quantified.Motion estimation is critical to many modern signal-processing algorithms. In medical imaging, for example, motion estimation is used to align images in extended field of view app...</description><pubDate>Wed, 07 Mar 2012 09:33:56 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9059</guid></item><item><title>Self-Integrated Sandwich Panel Design for Improved Strength, Reduced Failure Rate</title><caseId>M-WADLEY-WOVEN</caseId><link>http://uva.technologypublisher.com/technology/9058</link><description><![CDATA[Executive SummaryThe invention is a novel concept for eliminating the failure point of current sandwich panels, producing a structure that provides greater strength without an increase in weight.BackgroundComposite sandwich structures with a corrugated inner core make lightweight panels for applications ranging from ship hulls to armor. Currently, such panels are fabricated by stitching the inner corrugated material to flat facing sheets. While this method produces lightweight panels, the stitching is often a failure point, limiting the panels&rsquo; overall strength.Invention DescriptionThis ...]]></description><pubDate>Wed, 07 Mar 2012 09:33:55 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9058</guid></item><item><title>Novel Technique for More Efficient Vapor Deposition</title><caseId>M-WADLEY-COAXIAL</caseId><link>http://uva.technologypublisher.com/technology/9057</link><description>Executive SummaryThe invention involves a novel process and apparatus that use hollow cathode technology to improve any evaporation-based method for coating the surface of materials.BackgroundVapor deposition is a process for applying any form of coating to a material substrate. Although existing techniques are somewhat effective at performing vapor deposition, they typically face significant drawbacks. For instance, high flow rates of gas delivery are required, necessitating high-capacity pumps. In addition, with existing methods, the cathode-delivered gas jet is directed into the path of the...</description><pubDate>Wed, 07 Mar 2012 09:33:54 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9057</guid></item><item><title>Use of Monoclonal Antibodies to Target Cancer Cells</title><caseId>M-TAYLOR-CANCER</caseId><link>http://uva.technologypublisher.com/technology/9054</link><description>The use of monoclonal antibodies in cancer diagnosis and treatment, while promising, is also problematic. Current cancer therapies that rely on this technology require the identification of specific epitopes that are expressed at high levels for a given form of cancer but are expressed at low levels on normal tissues and the development of monoclonal antibodies specific for those epitopes that show minimal cross-reactivity with normal tissues. While most studies have worked to identify epitopes and their corresponding antibodies in order to diagnose and treat specific forms of cancer, research...</description><pubDate>Wed, 07 Mar 2012 09:33:52 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9054</guid></item><item><title>Inverted Well Plate for Large-Scale Cell Culture</title><caseId>M-STOCKS-HASCPLATE</caseId><link>http://uva.technologypublisher.com/technology/9052</link><description><![CDATA[


  
  
  
  
    Courtesy of Stocks, Peirce-Cottler, 
      Katz
Executive Summary&nbsp; This invention is the inverted 
complement of a 96-well plate made to increase cell transfer efficiency and 
decrease the time needed for high-quantity cell culture. Using this unique tool, 
cells are suspended and grown in an inverted position before being transferred 
to a standard 96-well plate for storage. 
BackgroundStandard culture and transfer of 
mammalian cells require repetitive pipetting of hanging drop cultures inside a 
petri dish by a technician. This method, however, is considered ineffici...]]></description><pubDate>Wed, 07 Mar 2012 09:33:50 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9052</guid></item><item><title>Human Mast Cell Line Ideal for Inflammation Studies</title><caseId>M-STEINKE-IMMORTAL</caseId><link>http://uva.technologypublisher.com/technology/9051</link><description><![CDATA[Executive SummaryThis technology is an immortalized human mast cell line that is easily cultured without growth factors and that has a high expression of Fc&epsilon;RI for investigating inflammation response.BackgroundMast cells exist in several types of tissues and play a role in allergy and anaphylaxis as a factor in inflammation response. They are also involved in wound healing and defense against pathogens. These cells express the high-affinity receptors that are specific to IgE, Fc&epsilon;RI, on their surface, making IgE molecules cell-surface receptors for an antigen. When bound IgE mol...]]></description><pubDate>Wed, 07 Mar 2012 09:33:49 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9051</guid></item><item><title>Phospho-Y694/699 STAT5A/B Antibody</title><caseId>M-SHUPNIK-H285</caseId><link>http://uva.technologypublisher.com/technology/9050</link><description>  Normal 0   false false false        MicrosoftInternetExplorer4       Production and Reactivity This chicken antibody was generated against a phospho-peptide of amino acids 690/4-701/6 of human STAT5A/B and recognizes only phosphorylated STAT5A/B.ApplicationsWB, IFReferencesMol Endocrinol. 2008 Aug;22(8):1781-96. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:33:48 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9050</guid></item><item><title>Super-Rich Hydrogen Storage Nanomaterials with Intermediate Bond Strength</title><caseId>M-SHIVARAM-STORAGE</caseId><link>http://uva.technologypublisher.com/technology/9049</link><description>The quest for vehicles powered by alternative sources of fuel such as hydrogen has led to an explosion of research into new materials for storing and releasing hydrogen. Currently, one of the main challenges in the large scale development of hydrogen as a fuel is that a convenient and economical storage system does not exist.
Hydrogen storage technologies face a number of key challenges: 1) they must be able to store enough hydrogen for a vehicle to have a reasonable driving range; 2) they must be sufficiently light and compact so as not to change the efficiency of the vehicle; and 3) they mus...</description><pubDate>Wed, 07 Mar 2012 09:33:47 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9049</guid></item><item><title>E. coli LacI Antibody</title><caseId>M-SCRABLE-LAC1</caseId><link>http://uva.technologypublisher.com/technology/9048</link><description>Production and Reactivity This mouse IgG1 monoclonal antibody was generated against E. coli LacI and recognizes recombinant proteins containing the LacI tag.Clone Number9A5ApplicationsWB, IF, IHCReferencesGenes Dev. 2001 Jun 15;15(12):1506-17. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:33:46 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9048</guid></item><item><title>Zizimin1 (CDC42 GEF) Antibody</title><caseId>M-SCHWARTZ-ZIZI1</caseId><link>http://uva.technologypublisher.com/technology/9047</link><description>Production and Reactivity This mouse IgG2a monoclonal antibody was generated against human zizimin1 and recognizes amino acids 1184-1215 of human and primate homologs.Clone Number8B3-C3-E4ApplicationsWB, IP, IF</description><pubDate>Wed, 07 Mar 2012 09:33:45 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9047</guid></item><item><title>RhoG Antibody</title><caseId>M-SCHWARTZ-RHOAB</caseId><link>http://uva.technologypublisher.com/technology/9046</link><description><![CDATA[Production and Reactivity This mouse IgG2a monoclonal antibody was generated against amino acids 161&ndash;180 of RhoG and recognizes human, mouse and rat homologs.Clone Number1F3-B3-E5ApplicationsWB, ELISAReferencesJ Cell Sci. 2008 Jun 15;121(Pt 12):1981-9.]]></description><pubDate>Wed, 07 Mar 2012 09:33:44 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9046</guid></item><item><title>High Sensitivity Infrared Sensing Apparatus</title><caseId>M-REED-LEVITATE</caseId><link>http://uva.technologypublisher.com/technology/9045</link><description>Researchers at the University of Virginia have developed a novel idea for IR sensor system design where the detector is suspended away from electrical and thermal connections. Sensitivity of such a system is expected to be an order of magnitude better than the current IR sensors.Infrared sensors have become widely used in many detection systems, most notably for night vision applications. The sensitivity of an infrared sensor is limited, however, by thermal losses in the detector itself. Typically, an infrared sensor consists of a suspended platform coated with material sensitive to infrared r...</description><pubDate>Wed, 07 Mar 2012 09:33:44 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9045</guid></item><item><title>An Improved Method for Diagnosing Seizures</title><caseId>M-QUIGG-LIMB</caseId><link>http://uva.technologypublisher.com/technology/9044</link><description>Executive SummaryThe invention is a novel patient-monitoring device that uses limb accelerometry to more accurately diagnose epileptic seizures (ES).BackgroundNearly 10 percent of Americans will experience at least one seizure during their lifetime. Unfortunately, however, seizures can be difficult to diagnose using existing technology and methods, which often face many practical challenges. For example, clinical observation of convulsive movements is subjective and often unreliable. Tools such as electroencephalography (EEG) and continuous video-EEG (CV-EEG) are cumbersome and have a variety ...</description><pubDate>Wed, 07 Mar 2012 09:33:42 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9044</guid></item><item><title>Lightweight Structures for Improving Performance of Aerospace Components</title><caseId>M-QUEHEIL-CORE</caseId><link>http://uva.technologypublisher.com/technology/9043</link><description>Invention DescriptionAerospace vehicles have many components that are subjected to high thermal and mechanical loading. In addition to heat and strength considerations, these components must be extremely lightweight in order to reduce associated fuel costs. The invention utilizes heat pipe concepts to improve heat transfer throughout cellular core panel structures. Specifically, these structures are well adapted to dissipate heat and withstand large static and dynamic forces, making them well suited for aerospace applications. A published Patent Cooperation Treaty (PCT) application covering th...</description><pubDate>Wed, 07 Mar 2012 09:33:42 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9043</guid></item><item><title>Amorphous Steel Composites and Methods for Their Manufacture</title><caseId>M-POON-STEEL</caseId><link>http://uva.technologypublisher.com/technology/9041</link><description>Amorphous steels exhibit superb mechanical properties for a variety of high-performance applications, but they are significantly more brittle than conventional high-carbon steels. The fracture toughness of this group of materials must be improved prior to utilizing them as structural components. Scientists at the University of Virginia have developed an amorphous steel composite that exhibits enhanced fracture strengths and elastic moduli, as well as fracture features that indicate improved ductility. They have also developed practical methodologies to successfully produce these composites. In...</description><pubDate>Wed, 07 Mar 2012 09:33:40 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9041</guid></item><item><title>Cytoplasmic Dynein Intermediate Chain Antibody (Clone 74.1)</title><caseId>M-PFISTER-MAB</caseId><link>http://uva.technologypublisher.com/technology/9040</link><description><![CDATA[Production and Reactivity:&nbsp; IgG2b mouse monoclonal antibody generated against bovine brain cytoplasmic dynein and recognizes an epitope in the N-terminal 60 amino acids of the intermediate chain (IC) subunit of cow, mouse, rat, dog, sheep, fish, xenopus, and drosophila homologs.&nbsp; The antibody blocks dynein function when injected into cells or cell extracts.Clone number:74.1Applications:WB, IP, IFReferences:&nbsp;&nbsp;&nbsp; J Cell Biol. 1994 Dec;127(6 Pt 1):1671-81.]]></description><pubDate>Wed, 07 Mar 2012 09:33:39 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9040</guid></item><item><title>Dynein Light Chain 1 (DYNLT1) Antibody</title><caseId>M-PFISTER-DYNT1</caseId><link>http://uva.technologypublisher.com/technology/9039</link><description>Production and Reactivity This mouse IgG1 monoclonal antibody was generated against human Dynein Light Chain 1 (DYNLT1) and recognizes rat and human homologs.Clone Number7A9-F4-H10ApplicationsWB, IFReferencesJ Biol Chem. 2007 Dec 21;282(51):36871-8.</description><pubDate>Wed, 07 Mar 2012 09:33:38 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9039</guid></item><item><title>Dynein Light Chain 3 (DYNLT3) Antibody</title><caseId>M-PFISTER-DYNR1</caseId><link>http://uva.technologypublisher.com/technology/9038</link><description>Production and Reactivity This mouse IgG2a monoclonal antibody was generated against rat Dynein Light Chain 3 (DYNLT3) and recognizes rat and human homologs.Clone Number10A3-C8-A1ApplicationsWB, IFReferencesJ Biol Chem. 2007 Dec 21;282(51):36871-8.</description><pubDate>Wed, 07 Mar 2012 09:33:38 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9038</guid></item><item><title>Sno Knockout Mouse Strain</title><caseId>M-PEARSON-MOUSE</caseId><link>http://uva.technologypublisher.com/technology/9037</link><description>Reagent DescriptionThese mutant mice may be useful in studies of T cell activation, T cell receptor stimulation and TGF-beta signaling. A targeting vector was designed to replace exon 1 of the endogenous gene with a lacZ gene (with a nuclear localization signal) and a loxP-flanked PGK-neo cassette. This construct was microinjected into (129X1/SvJ x 129S1/Sv)F1-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts, which were then implanted into pseudopregnant foster mothers, resulting in heterozygous offspring. These mice were then backcrossed...</description><pubDate>Wed, 07 Mar 2012 09:33:37 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9037</guid></item><item><title>Androgen Receptor Antibody (AR21)</title><caseId>M-PASCHAL-ANDROGEN</caseId><link>http://uva.technologypublisher.com/technology/9035</link><description>Production and Reactivity This rabbit polyclonal antibody was generated against the N-terminal 21 amino acids of human androgen receptor (AR).ApplicationsWB, IP, IFReferencesMol Cell Biol. 2007 May;27(9):3390-404. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:33:35 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9035</guid></item><item><title>p120/Catenin Antibody (Clone 2B12)</title><caseId>M-PARSONS-P1202B12</caseId><link>http://uva.technologypublisher.com/technology/9034</link><description>Production and Reactivity This mouse IgG1 antibody was generated against tyrosine phosphoproteins purified from chicken embryonic fibroblasts (CEFs) expressing pp60/c-src 527F and 2A/527F. It recognizes mouse, rat, hamster, human and chicken homologs of p120/catenin.Clone Number2B12ApplicationsWB, IPReferencesProc Natl Acad Sci U S A. 1990 May;87(9):3328-32. (Available online.) Mol Cell Biol. 1991 Feb;11(2):713-20. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:33:35 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9034</guid></item><item><title>Phospho-Tyrosine Antibody</title><caseId>M-PARSONS-6G9JP01</caseId><link>http://uva.technologypublisher.com/technology/9033</link><description>Production and Reactivity This mouse IgG2a antibody was generated against tyrosine phospho-proteins purified from chicken embryonic fibroblasts (CEFs) expressing pp60/c-src 527F and 2A/527F and recognizes tyrosine phospho-proteins in mouse, rat, hamster, human and chicken cell lines.Clone Number6G9ApplicationsWB, IPReferencesProc Natl Acad Sci U S A. 1990 May;87(9):3328-32. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:33:34 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9033</guid></item><item><title>Neutrophil-Specific, NIR Fluorescent Imaging Agent</title><caseId>M-PAN-CY7PEPTIDE</caseId><link>http://uva.technologypublisher.com/technology/9032</link><description>


  
  
  
  
    Courtesy of Pan, Zhang, 
    Xiao


  
  
  
  
    This figure shows NIR fluorescence 
      image three hours after injection of cFLFLF-PEG76-Cy7 in a mouse model of 
      ear inflammation. (A) shows probe accumulation in the PMA-treated ear. (B) 
      shows probe specificity shown by pre-injection with a non-fluorescence 
      peptide.
Reagent Description This reagent is a Cy7-conjugated, 
PEG-modified hexapeptide that specifically binds the formyl peptide receptor 
(FPR) of neutrophils. After tail vein injection of the agent, sites of 
inflammation, where neutrophils ...</description><pubDate>Wed, 07 Mar 2012 09:33:33 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9032</guid></item><item><title>GnRH Neuron GFP-Expressing Mouse Strain</title><caseId>M-MOENTER-GNRHGFP</caseId><link>http://uva.technologypublisher.com/technology/9028</link><description><![CDATA[Reagent DescriptionThis transgenic mouse line expresses the reporter green fluorescent protein (GFP) under the control of the mouse gonadotrophin-releasing hormone (GnRH) promoter. This allows the identification of GnRH neurons in the brain without further processing. Founder strain CBB6/F1 was partially backcrossed onto C57BL6/J so that current mice are approximately 75&ndash;80 percent C57BL6/J based on speed congenic analyses. Mice are homozygous for the transgene.
  Normal 0   false false false        MicrosoftInternetExplorer4       
ReferencesEndocrinology. 2000 Jan;141(1):412-9. (Availa...]]></description><pubDate>Wed, 07 Mar 2012 09:33:30 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9028</guid></item><item><title>Circadian Rhythm-Induced Luciferase Expression in a Rat Strain</title><caseId>M-MENAKER-CIRCAD</caseId><link>http://uva.technologypublisher.com/technology/9027</link><description>Reagent DescriptionThis rat strain is useful for studying the organization of the mammalian circadian system. In this transgenic rat line, luciferase is rhythmically expressed under the control of the mouse Per1 promoter. Cells isolated from the suprachiasmatic nuclei (SCN) continue rhythmical light emission for up to 32 days in vitro. A mouse Per1 genomic fragment of 6.7 kb was ligated directly to the second codon of the firefly luciferase cDNA flanked by the SV40 late polyadenylation signal. The mPer1 fragment includes five functional E box regions, a transcription initiation site, the first...</description><pubDate>Wed, 07 Mar 2012 09:33:29 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9027</guid></item><item><title>Crohn's Disease Mouse Model</title><caseId>M-X-SXBMICE</caseId><link>http://uva.technologypublisher.com/technology/9026</link><description><![CDATA[Reagent DescriptionSAMP1/YitFcs (also called SAMP1/YitFc or SAMP1/Fc) mice develop a spontaneous ileitis that is similar in many features to human Crohn&rsquo;s disease. Development of ileitis is accelerated by the presence of luminal bacteria and is characterized by discontinuous segmental inflammation involving the ileum while sparing the proximal small intestine and colon. The histopathologic features of SAMP1/Fc ileitis include transmural inflammation, crypt abscesses and epithelial changes such as loss of villi, crypt elongation and crypt branching. SAMP1/Fc mice were originally distingui...]]></description><pubDate>Wed, 07 Mar 2012 09:33:29 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9026</guid></item><item><title>Diabetes-Resistant Mouse Strains</title><caseId>M-MCDUFFIE-MOUSE</caseId><link>http://uva.technologypublisher.com/technology/9025</link><description><![CDATA[Reagent DescriptionThese mouse strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are useful for identifying candidate genes within the Idd4 subloci.&nbsp; Strain 008053 and 008061 are known in the literature as DR3 and DR4, respectively.Strains 008062, 008063 and 008064 are reported to be both diabetes- and lupus-resistant.A full description of the strains can be found at the Jackson Laboratory website using the links below. Use of this strain by companies or for-profit entities r...]]></description><pubDate>Wed, 07 Mar 2012 09:33:28 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9025</guid></item><item><title>SIMPLE: A Novel Immunohistochemical Method for Multiple Antigen Labeling</title><caseId>M-MANDELL-SIMPLE</caseId><link>http://uva.technologypublisher.com/technology/9024</link><description>Executive Summary

A new method for immunohistochemical (IHC) staining allowing colocalization studies of six or more proteins within a single tissue section.Background 

Visual colocalization of molecular species within sectioned tissue can provide powerful insights into cellular biochemistry and often provides the basis for further study of protein-protein interactions. However, current methods are imperfect and are limited to at most three simultaneous probes. Multi-color fluorescence is limited by few non-overlapping combinations of fluorescent tags, antibody cross-reactivity, photobleachi...</description><pubDate>Wed, 07 Mar 2012 09:33:27 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9024</guid></item><item><title>Sept6 Antibody</title><caseId>M-MACARA-ABSEPT6</caseId><link>http://uva.technologypublisher.com/technology/9023</link><description>Production and Reactivity This mouse monoclonal antibody was generated against a tetramer of GST-BD3/Sept2/Sept6/Sept7 and recognizes human and canine homologs of Sept6.Clone number9E7ApplicationsWB, IPReferencesMol Biol Cell. 2005 Oct;16(10):4648-59.</description><pubDate>Wed, 07 Mar 2012 09:33:26 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9023</guid></item><item><title>Novel Targets in Treating Erectile Dysfunction</title><caseId>M-LYSIAK-ED</caseId><link>http://uva.technologypublisher.com/technology/9022</link><description>


  
  
  
  
    Courtesy Lysiak, Palmer, 
      Kavoussi


  
  
  
  
    Figure 1. Heterozygote and 
      knockout mice are unable to maintain erections. When the cavernous nerve 
      is stimulated, wild type mice (blue) are able to maintain high 
      intracavernous pressures (ICPs) for approximately five minutes, whereas 
      both heterozygote (green) and knockout (red) mice are only able to 
      initiate a blunted ICP response without the ability to sustain an 
      erection.
Erectile dysfunction (ED) is a major health problem affecting approximately 
30 million men in the Uni...</description><pubDate>Wed, 07 Mar 2012 09:33:25 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9022</guid></item><item><title>Adenosine Receptor-Expressing HEK293 and CHO-K1 Cell Lines</title><caseId>M-LINDEN-EXPRESS</caseId><link>http://uva.technologypublisher.com/technology/9021</link><description>DescriptionThese HEK293 and CHO-K1 cells stably express all four types of human adenosine receptors. Membranes prepared from these cells can be used to screen compounds to determine their affinities for human adenosine receptors. U.S. patent 5,854,081 has been issued on this technology.ReferencesBiochem Pharmacol. 1996 Feb 23;51(4):545-55. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:33:25 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9021</guid></item><item><title>Ga i-2 Antibody (Clone 5C11)</title><caseId>M-LINDEN-ANTIGI</caseId><link>http://uva.technologypublisher.com/technology/9020</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG1 monoclonal antibody generated against rat G&alpha; i-2 and recognizes rat and human homologs. Additional species reactivity and applications have not been tested.Clone number:5C11-B4Applications:WB]]></description><pubDate>Wed, 07 Mar 2012 09:33:24 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9020</guid></item><item><title>Adenosine Receptor A2A Antibody (Clone 7F6)</title><caseId>M-LINDEN-7F6G5A2</caseId><link>http://uva.technologypublisher.com/technology/9019</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG2a monoclonal antibody generated against human Adenosine Receptor A2A and recognizes the 3rd intracellular loop (amino acids 213-220) of human, mouse, rabbit, dog, and rat homologs.Clone number:7F6-G5-A2Applications:WB, IF, IHC, FCReferences:&nbsp;&nbsp;&nbsp; J Comp Neurol. 1998 Nov 16;401(2):163-86.Drug Dev Res. 1996;39(3-4):243-252. Mol Pharmacol. 1999 Mar;55(3):614-24.]]></description><pubDate>Wed, 07 Mar 2012 09:33:23 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9019</guid></item><item><title>Novel Hip Rehabilitation Device for Improved Range of Motion</title><caseId>M-LEE2-HIPCPM</caseId><link>http://uva.technologypublisher.com/technology/9018</link><description>Executive SummaryThis invention is a novel device that provides continuous passive motion physiotherapy to patients following hip surgery or replacement procedures. The novel design incorporates both flexion and extension of the hip joint, providing the complete range of motion necessary for rehabilitation. BackgroundContinuous passive motion (CPM) physiotherapy helps patients regain their natural range of motion and also improves patient comfort following joint surgery or injury. Although effective devices exist for knee and shoulder CPM, no device currently exists for effective hip CPM. Whil...</description><pubDate>Wed, 07 Mar 2012 09:33:22 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9018</guid></item><item><title>BM180 (Basement Membrane Protein, 180kDa) Antibody</title><caseId>M-LAURIE-SJOGREN</caseId><link>http://uva.technologypublisher.com/technology/9017</link><description><![CDATA[Production and Reactivity This rat IgG2a antibody was generated against a laminin-depleted basement membrane protein extracted from a mouse EHS tumor cell line. It recognizes BM180, a novel basement membrane protein with a role in regulated tear secretion by lacrimal acinar cells, and may be involved in Sjogren&rsquo;s syndrome. U.S. patent 5,895,812 has been issued on this technology.Clone Number3E12ApplicationsWB, IHC, ELISAReferencesAm J Physiol. 1996 Jun;270(6 Pt 1):C1743-50.]]></description><pubDate>Wed, 07 Mar 2012 09:33:21 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9017</guid></item><item><title>Improving the Accuracy of Continuous Glucose Sensors for Type 1 and Type 2 Diabetes</title><caseId>M-KOVATCHEV-SENSOR</caseId><link>http://uva.technologypublisher.com/technology/9014</link><description>BackgroundContinuous glucose sensors (CGSs) offer the potential to markedly change our understanding of glucose homeostasis in health and disease and to provide the missing information required to achieve near-normoglycemia among persons with both Type 1 and Type 2 diabetes. Despite their having appeared on the scene less than five years ago, CGSs already have been shown to be associated with short-term reductions in glucose variability, time spent in nocturnal hypoglycemia, time spent in hyperglycemia and lower glycosylated hemoglobin values. Their potential to assist patients and their famil...</description><pubDate>Wed, 07 Mar 2012 09:33:17 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9014</guid></item><item><title>Method, System and Computer Program Product for the Detection of Physical Activity by Changes in Heart Rate, Assessment of Fast-Changing Metabolic States and Applications of Closed and Open Control Loop in Diabetes</title><caseId>M-KOVATCHEV-HEARTRAT</caseId><link>http://uva.technologypublisher.com/technology/9013</link><description><![CDATA[For the more than three million people in the U.S. suffering from Type I diabetes (T1DM), the majority of whom are children, the daily tasks required to manage the disease &mdash; such as eight to 10 needle pricks, constant worrying over what to eat and how to control one's blood sugar, and self-injection of medication multiple times daily &mdash; can be burdensome and overwhelming. Type I diabetics, in particular, have reason to be enthusiastic with the promising developments in the area of insulin pumps and continuous glucose monitors (CGM). These devices are designed to simulate an artifici...]]></description><pubDate>Wed, 07 Mar 2012 09:33:15 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9013</guid></item><item><title>Method and System for Capillary Force Actuators</title><caseId>M-KNOSPE-ACTUATOR</caseId><link>http://uva.technologypublisher.com/technology/9012</link><description>For micro-electromechanical systems (MEMS) and bio-MEMS (e.g., micro total analysis systems, or MTAS), a variety of force actuation methods have been used to either move structures or to induce stress in stationary structures, including electromagnetic, electrostatic, pneumatic, thermal, piezoelectric, magnetostrictive, among others. Each of these actuation technologies has advantages, disadvantages and trade-offs in terms of performance metrics such as force capability, total displacement, actuation bandwidth, ease of integration to particular applications, and manufacturability. Electrostati...</description><pubDate>Wed, 07 Mar 2012 09:33:13 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9012</guid></item><item><title>NORE1A Antibodies</title><caseId>M-KHOKHLATCHEV-NORE</caseId><link>http://uva.technologypublisher.com/technology/9010</link><description><![CDATA[Production and ReactivityThese mouse monoclonal antibodies were generated against amino acids 119&ndash;416 of human NORE1A. 



Clone Number
Isotype
Epitope
Applications 


10F10-C6-C6
IgG1
Amino acids 119&ndash;190, a unique sequence in the NORE1A splice isoform
WB, IF


7C11-C5-D7
IgG2a
Amino acids 363&ndash;416, a sequence present in both NORE1A and NORE1B isoforms
IP, IF





ReferencesJ Biol Chem. 2006 Mar 24;281(12):8143-52.]]></description><pubDate>Wed, 07 Mar 2012 09:33:12 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9010</guid></item><item><title>GABA-A Receptor Gamma2 Subunit Antibody</title><caseId>M-KAPUR-GABA</caseId><link>http://uva.technologypublisher.com/technology/9009</link><description><![CDATA[Production and Reactivity This mouse IgG2b monoclonal antibody was generated against amino acids 37&ndash;53 of the rat GABA-A receptor gamma2 subunit.Clone Number10F10-C1-B8ApplicationsWB, ELISA, IF, IHC]]></description><pubDate>Wed, 07 Mar 2012 09:33:11 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9009</guid></item><item><title>NOS (Nitric Oxide Synthase) Antibody (Clone 3F7)</title><caseId>M-JOHNS-MAB</caseId><link>http://uva.technologypublisher.com/technology/9008</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgM monoclonal antibody generated against bovine NOS and recognizes bovine, mouse, and rat eNOS, iNOS, and bNOS homologs.Clone number:3F7-B11-B5Applications:WB, IHCReferences:&nbsp;&nbsp;&nbsp; Am J Physiol. 1994 Dec;267(6 Pt 1):L704-11.]]></description><pubDate>Wed, 07 Mar 2012 09:33:10 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9008</guid></item><item><title>Adaptive Brain Stimulation Technique for Next-Generation Neuromodulation Therapy</title><caseId>M-HUDSON-FEEDBACK</caseId><link>http://uva.technologypublisher.com/technology/9005</link><description><![CDATA[Executive SummaryThe invention is a novel brain stimulation technique that uses a dynamic stimulation algorithm for controlling neuronal behavior within the brain, decreasing power consumption and improving efficacy of neuromodulation procedures.BackgroundNeuromodulation is a rapidly growing medical therapy which is being tested to treat diseases such as epilepsy, Alzheimer&rsquo;s Disease, tremors associated with Parkinson&rsquo;s Disease, and potentially many other neurological conditions. The procedure typically involves the surgical implantation of an electrode to apply electrical signals ...]]></description><pubDate>Wed, 07 Mar 2012 09:33:05 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9005</guid></item><item><title>New Platform for Targeted Intravascular Drug and Gene Delivery</title><caseId>M-HOSSACK-HYPERPLASI</caseId><link>http://uva.technologypublisher.com/technology/9004</link><description>Executive SummaryThis novel device combines the imaging capabilities of intravascular ultrasound (IVUS) with the therapeutic effectiveness of targeted microbubbles. The result is a new paradigm for targeted drug and gene delivery that yields safer and more effective treatments. This device also enables treatment of diseases for which therapy is currently limited and not effective, such as peripheral artery disease.BackgroundTraditional or systemic treatment of diseases requires dosing patients in excess of the minimum therapeutically effective dose, which can lead to unnecessary off-target eff...</description><pubDate>Wed, 07 Mar 2012 09:33:03 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9004</guid></item><item><title>Novel Treatment for Improved Heart Function Following Heart Attack</title><caseId>M-HOLMES-HEART</caseId><link>http://uva.technologypublisher.com/technology/9003</link><description>Executive SummaryUniversity of Virginia researchers have developed a novel treatment that dramatically improves heart function after a heart attack by modifying the mechanical characteristics of the affected region (the infarct).BackgroundOnce the myocardium dies during a heart attack, it is gradually replaced over the course of several weeks by scar tissue, accompanied by loss of pumping effectiveness, dilation of the left ventricle and eventual heart failure. Current therapies aim to limit damage during the first few hours by reopening coronary arteries and then slow remodeling and progressi...</description><pubDate>Wed, 07 Mar 2012 09:33:01 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9003</guid></item><item><title>Scientific Chart Depicts the Stages of Normal Hematopoiesis in Actual Human Blood Cells</title><caseId>M-HESS-HEMATOPOIESIS</caseId><link>http://uva.technologypublisher.com/technology/9002</link><description>The maturation of hematopoietic cells in human bone marrow is essential to the understanding of the process of hematopoiesis for physicians, pathologists, medical students, laboratory technologists, teachers and researchers. Yet to date, no single chart or reference guide exists that depicts all of the stages as shown in photographed human blood cells. Scientists from the University of Virginia led by Charles E. Hess, M.D., have created and assembled an extensive image database of unique benign and malignant diseases and disorders within human blood and bone marrow. From this comprehensive dat...</description><pubDate>Wed, 07 Mar 2012 09:33:00 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9002</guid></item><item><title>Semen Collection and Storage Device</title><caseId>M-HERR-COLLECT</caseId><link>http://uva.technologypublisher.com/technology/9001</link><description>Executive SummaryThis technology is a semen collection device that is better than all other collection devices at recovering ejaculated semen completely, preventing the loss of initial sperm-rich epididymal fractions.BackgroundSemen analysis is the major step to determine fertility of male patients and sperm donors. It requires clinical analysis by a trained medical professional under a microscope, or, increasingly, testing at home with other methods which requires high concentrations of sperm. Freshly ejaculated semen is a complex mixture where the sperm is concentrated in fluid from the epid...</description><pubDate>Wed, 07 Mar 2012 09:32:59 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/9001</guid></item><item><title>CD52 Antibody</title><caseId>M-HERR-ANTICD52</caseId><link>http://uva.technologypublisher.com/technology/8999</link><description>Production and Reactivity This mouse IgG1 monoclonal antibody generated against human spermatozoa and recognizes a carbohydrate epitope on the spermatozoa glycoform of CD52.Clone NumberS19 (MHS8-A5-A1-D7)ApplicationsWB, IP, IF, IHCReferencesFASEB J. 1999 Aug;13(11):1303-13.</description><pubDate>Wed, 07 Mar 2012 09:32:56 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8999</guid></item><item><title>Synthesis Method for RSK Inhibitor SL0101</title><caseId>M-HECHT-GINGER</caseId><link>http://uva.technologypublisher.com/technology/8998</link><description>


  
  
  
  
    Courtesy of Hecht, 
  Maloney
Executive SummaryThe invention involves a practical 
synthesis of the Rsk2 inhibitor and potential antitumor agent SL0101-1 and 
analogues.BackgroundRecent studies have 
demonstrated the role of Rsk in cell survival signaling and promoting cell 
survival by regulating the expression and activation of pro-survival proteins 
such as CREB. This combination of promoting cell survival and prevention of 
apoptosis causes excessive cell survival, leading to diseases such as cancer and 
autoimmune disorders. It has been found that Rsk2 is over-expressed...</description><pubDate>Wed, 07 Mar 2012 09:32:55 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8998</guid></item><item><title>Improved Process for Enhanced Electromagnetic Interference (EMI) Shielding</title><caseId>M-GUPTA-SHIELD</caseId><link>http://uva.technologypublisher.com/technology/8997</link><description><![CDATA[Executive SummaryUniversity of Virginia researchers have developed a novel foam carbon nanofiber&ndash;polymer composite material that provides a lightweight and durable solution for electromagnetic interference (EMI) shielding. BackgroundEMI shielding is required to protect electronics from electromagnetic energy interference; this characteristic is especially valued for products containing sensitive electronic components that, when disturbed, could yield catastrophic results. EMI shielding has many important applications, especially those in the computer, antenna systems, medical devices, te...]]></description><pubDate>Wed, 07 Mar 2012 09:32:54 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8997</guid></item><item><title>Device for Extending Laparoscopic Incisions for Safe and Rapid Removal of Gallbladder or other Specimens</title><caseId>M-GUILFORD-LAPARO</caseId><link>http://uva.technologypublisher.com/technology/8996</link><description><![CDATA[Executive SummaryUniversity of Virginia physicians have developed an inventive device to aid surgeons in safely removing patients&rsquo; gall bladders when complications arise that put patients at increased risk of harm and morbidity.BackgroundCholecystitis, or inflammation of the gallbladder, is among the most costly gastrointestinal diseases. The condition is frequently treated with laparoscopic cholecystectomy, a common surgical procedure performed on nearly one million patients annually in the U.S.During this procedure, surgeons frequently have difficulty extracting the gall bladder from t...]]></description><pubDate>Wed, 07 Mar 2012 09:32:53 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8996</guid></item><item><title>Human Cytokeratin 8 Antibody</title><caseId>M-GONIAS-ABCYTO8</caseId><link>http://uva.technologypublisher.com/technology/8994</link><description>Production and ReactivityThis mouse IgG2b antibody has been generated against the C-terminus (amino acids 472-483) of human Cytokeratin 8.Clone Number1E8-C6-B4ApplicationsWB, IP, IFReferencesJ Biol Chem. 1996 Oct 11;271(41):25684-91.</description><pubDate>Wed, 07 Mar 2012 09:32:51 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8994</guid></item><item><title>Accurate Method for Measuring Nitric Oxide in Blood</title><caseId>M-GASTON-CHLORIDE</caseId><link>http://uva.technologypublisher.com/technology/8990</link><description>Executive SummaryResearchers at the University of Virginia have developed a novel method of detecting nitric oxide (NO) levels in heme-containing samples such as blood.BackgroundBlood gas analysis is typically used to determine the amount of oxygen and carbon dioxide carried in the blood. A third blood gas, nitric oxide (NO), is however not currently measured by routine analysis. NO signaling is abnormal in a variety of human diseases, including asthma, cystic fibrosis, sepsis, diabetes, pulmonary hypertension and sickle cell anemia, among others. Measurement of NO levels in the blood can aid ...</description><pubDate>Wed, 07 Mar 2012 09:32:47 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8990</guid></item><item><title>Combined ECG-Echo for Cardiac Diagnosis</title><caseId>M-GARSON-COMBINED</caseId><link>http://uva.technologypublisher.com/technology/8988</link><description>The most common tool for cardiac screening and diagnosis, the electrocardiogram (ECG) is at best an indirect measure of cardiac dimensions. Specific dimensions of interest including chamber volumes, wall thickness and septal thickness can only be indirect assessed by ECG with overall poor predictive value for these measurements. Historically the ECG has achieved widespread clinical application because of its ease of use and relatively low cost, even though it fails to accurately reflect chamber size and wall thickness. The ECG does provide important information on heart rhythm, possible ischem...</description><pubDate>Wed, 07 Mar 2012 09:32:46 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8988</guid></item><item><title>CD40 Antibody</title><caseId>M-FU-CD40</caseId><link>http://uva.technologypublisher.com/technology/8987</link><description>Production and ReactivityThis mouse IgG1 antibody has been generated against human activated tonsillar B cells and recognizes human CD40.Clone Number626ApplicationsWB, IHC, FCReferencesJ Immunol. 1989 Jun 15;142(12):4144-52.</description><pubDate>Wed, 07 Mar 2012 09:32:45 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8987</guid></item><item><title>Bruton's Tyrosine Kinase (BTK) Antibody</title><caseId>M-FU-ABBTK</caseId><link>http://uva.technologypublisher.com/technology/8986</link><description><![CDATA[Production and ReactivityThis mouse IgG1 monoclonal antibody has been generated against the PH domain (amino acids 1&ndash;175) of human BTK and recognizes human and rat homologs.Clone Number10D11ApplicationsWB, IPReferencesAm J Hum Genet. 1996 Mar;58(3):477-83.]]></description><pubDate>Wed, 07 Mar 2012 09:32:44 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8986</guid></item><item><title>Mechanochromic Chemical Sensors</title><caseId>M-FRASER-MECHANO</caseId><link>http://uva.technologypublisher.com/technology/8985</link><description>


  
  
  
  
    Courtesy of Fraser 
  Lab
Executive SummaryResearchers at the University of 
Virginia have developed a family of light-emitting boron dye compounds that are 
easily tuned and that change appearance with scratching and 
heating.BackgroundChemical dyes are used for 
innumerable applications, from biomedical diagnosis to LEDs in television 
screens. The application of each particular dye is a function of its 
environmental sensitivity, intensity and wavelength, among other features. 
Few chemical dyes, however, show useful changes in appearance with 
mechanical perturbance, suc...</description><pubDate>Wed, 07 Mar 2012 09:32:43 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8985</guid></item><item><title>Dual Fluorescent/Phosphorescent Oxygen Sensors</title><caseId>M-FRASER-BORON</caseId><link>http://uva.technologypublisher.com/technology/8984</link><description>


  
  
  
  
    Courtesy of Fraser 
  Lab


  
  
  
  
    Samples exhibiting the tunable 
      wavelength of the boron dyes
Executive SummaryResearchers at the University of 
Virginia have developed a family of light-emitting boron dye compounds that are 
easily tuned and that emit fluorescence and oxygen-sensitive phosphorescence 
after illumination. BackgroundChemical dyes are 
used for innumerable applications, from biomedical diagnosis to LEDs in 
television screens. The application of each particular dye is a function of its 
environmental sensitivity, intensity and wavelength, amon...</description><pubDate>Wed, 07 Mar 2012 09:32:43 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8984</guid></item><item><title>MAP1B Antibody (Clone AA9)</title><caseId>M-FRANKFURTER-AA9</caseId><link>http://uva.technologypublisher.com/technology/8983</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG2a monoclonal antibody generated against rat brain tubulin and recognizes mammalian MAP1B homologs.Clone number:AA9Applications:WB, IP, IF, IHC]]></description><pubDate>Wed, 07 Mar 2012 09:32:42 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8983</guid></item><item><title>MAP2 Antibody (Clone AA6)</title><caseId>M-FRANKFURTER-AA6</caseId><link>http://uva.technologypublisher.com/technology/8982</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG2a monoclonal antibody generated against rat brain tubulin and recognizes the high molecular weight forms of mammalian MAP2 homologs.Clone number:AA6Applications:WB, IP, IF, IHCReferences:&nbsp;&nbsp;&nbsp; J Neurosci. 1988 Dec;8(12):4503-12.]]></description><pubDate>Wed, 07 Mar 2012 09:32:41 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8982</guid></item><item><title>MAP2 Antibody (Clone AA5)</title><caseId>M-FRANKFURTER-AA5</caseId><link>http://uva.technologypublisher.com/technology/8981</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG2a monoclonal antibody generated against rat brain tubulin and recognizes the high molecular weight forms of mammalian MAP2 homologs.Clone number:AA5Applications:WB, IP, IF, IHCReferences:&nbsp;&nbsp;&nbsp; J Neurosci. 1988 Dec;8(12):4503-12. ]]></description><pubDate>Wed, 07 Mar 2012 09:32:40 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8981</guid></item><item><title>B-Tubulin Antibody (Clone AA2)</title><caseId>M-FRANKFURTER-AA2</caseId><link>http://uva.technologypublisher.com/technology/8980</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG1 monoclonal antibody generated against bovine brain tubulin and recognizes amino acids 416-431, one of the most highly conserved regions in both plant and animal &beta;-tubulins. The antibody cross-reacts with human, mouse, rat, and bovine homologs of &beta;-tubulin types I, II, III, and IV and is expected to recognize homologs in many species based on sequence conservation.Clone number:AA2Applications:WB, IP, IF, IHC
References: &nbsp;J Comp Neurol. 1996 Jan 8;364(2):219-30.Methods Cell Biol. 2010;95:33-46.]]></description><pubDate>Wed, 07 Mar 2012 09:32:40 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8980</guid></item><item><title>BV-Tubulin Antibody (Clone AA17)</title><caseId>M-FRANKFURTER-AA17</caseId><link>http://uva.technologypublisher.com/technology/8979</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG1 monoclonal antibody generated against the C-terminal 20 amino acids of &beta;V-tubulin (DATANDGEEAFEDEEEEIDG) and recognizes the human homolog.Clone number:AA17Applications:WB, IHC]]></description><pubDate>Wed, 07 Mar 2012 09:32:39 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8979</guid></item><item><title>BVI-Tubulin Antibody (Clone AA16)</title><caseId>M-FRANKFURTER-AA16A</caseId><link>http://uva.technologypublisher.com/technology/8978</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG2a monoclonal antibody generated against the last 17 amino acids (DEEVTEEAEMEPEDKGH) of human &beta;VI-tubulin, found exclusively in megakaryocytes and platelets.Clone number:AA16Applications:WB, IHC]]></description><pubDate>Wed, 07 Mar 2012 09:32:38 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8978</guid></item><item><title>a-Tubulin Antibody (Clone AA13)</title><caseId>M-FRANKFURTER-AA13</caseId><link>http://uva.technologypublisher.com/technology/8977</link><description><![CDATA[Production and Reactivity:&nbsp; IgG2a mouse monoclonal antibody generated against rat brain tubulin recognizes mammalian homologs of &alpha;-tubulin.Clone number:AA13Applications:WB, IP, IF, IHC, ELISA]]></description><pubDate>Wed, 07 Mar 2012 09:32:37 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8977</guid></item><item><title>Detyrosinated  a-Tubulin Antibody (Clone AA12)</title><caseId>M-FRANKFURTER-AA12</caseId><link>http://uva.technologypublisher.com/technology/8976</link><description><![CDATA[Production and Reactivity:&nbsp; IgG2a mouse monoclonal antibody generated against an &alpha;-tubulin peptide (GEEEGE) and recognizes mammalian homologs of detyrosinated &alpha;-tubulin.Clone number:AA12Applications:WB, IP, IF, IHCReferences:&nbsp;&nbsp;&nbsp; Mol Cancer Ther. 2006 Nov;5(11):2824-33.]]></description><pubDate>Wed, 07 Mar 2012 09:32:37 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8976</guid></item><item><title>BIII Tubulin Antibody (Clone AA10)</title><caseId>M-FRANKFURTER-AA10</caseId><link>http://uva.technologypublisher.com/technology/8975</link><description><![CDATA[Production and ReactivityThis mouse IgG2a monoclonal antibody has been generated against amino acids 436&ndash;450 of &beta;-tubulin type III (neuronal) and recognizes human, mouse, rat and bovine homologs. It is expected to cross-react with all mammalian homologs based on highly conserved sequences. The epitope recognized by AA10 (EAQGPK) is the same as the inventor's other &beta;III-specific antibodies: 2G10, TuJ1 and 5G8.Clone numberAA10ApplicationsWB, IP, IF, IHC]]></description><pubDate>Wed, 07 Mar 2012 09:32:36 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8975</guid></item><item><title>BII Tubulin Antibody (Clone 7B9)</title><caseId>M-FRANKFURTER-7B9</caseId><link>http://uva.technologypublisher.com/technology/8974</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG1 monoclonal antibody generated against the c-terminus of beta II tubulin (CEEEEGEDEA) and recognizes mammalian homologs. The epitope recognized by 7B9 is the same as Dr. Frankfurter&rsquo;s other &beta;II-specific antibody, 6B1.Clone number:7B9-D6-G12Applications:WB, IP, IFReferences:&nbsp;&nbsp;&nbsp; J Comp Neurol. 1996 Jan 8;364(2):219-30.Methods Cell Biol. 2010;95:33-46.]]></description><pubDate>Wed, 07 Mar 2012 09:32:35 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8974</guid></item><item><title>BII Tubulin Antibody (Clone 6B1)</title><caseId>M-FRANKFURTER-6B1</caseId><link>http://uva.technologypublisher.com/technology/8973</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG3 monoclonal antibody generated against the c-terminus of beta II tubulin (CEEEEGEDEA) and recognizes mammalian homologs.&nbsp; The epitope recognized by 6B1 is the same as Dr. Frankfurter&rsquo;s other &beta;II-specific antibody, 7B9.Clone number:6B1-C1-H3Applications:WB, IF
References:Cell Motil Cytoskeleton. 1998;39(2):107-21.Methods Cell Biol. 2010;95:33-46.]]></description><pubDate>Wed, 07 Mar 2012 09:32:34 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8973</guid></item><item><title>BIII Tubulin Antibody (Clone 2G10)</title><caseId>M-FRANKFURTER-2G10</caseId><link>http://uva.technologypublisher.com/technology/8972</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG2a monoclonal antibody generated against amino acids 436-450 of beta tubulin type III (neuronal) and recognizes human, mouse, rat, and bovine homologs. Expected to cross-react with all mammalian homologs based on highly conserved sequences. The epitope recognized by 2G10 (EAQGPK) is the same as Dr. Frankfurter&rsquo;s other &beta;III-specific antibodies, AA10, TuJ1, and 5G8.Clone number:2G10-E9-B1-F7Applications:WB, IP, IF, IHC
References:Methods Cell Biol. 2010;95:33-46.]]></description><pubDate>Wed, 07 Mar 2012 09:32:34 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8972</guid></item><item><title>SCID Mouse Model Expressing Human HLA-A2.1</title><caseId>M-ENGELHARD-MOUSEPRK</caseId><link>http://uva.technologypublisher.com/technology/8969</link><description><![CDATA[Reagent DescriptionNOD.CB17-PrkdcSCID (SCID mouse) was crossed once with NOD.B6-TgN(HLA-A2.1)1Enge/Dvs, and the doubly heterozygous offspring were backcrossed once to NOD.CB17-PrkdcSCID, to make the strain homozygous for Prkdc SCID, then sibling-mated to fix the strain homozygous for TgN(HLA-A2.1)1Enge.&nbsp;A full description can be found at the Jackson Laboratory, where this strain is sold as stock number 004262. Use of this strain by companies or for-profit entities requires a license from the U.Va. Patent Foundation.Strain NameNOD.Cg-PrkdcscidTg (HLA-A2.1)1Enge/DvsReferencesClin Immunol. 2...]]></description><pubDate>Wed, 07 Mar 2012 09:32:31 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8969</guid></item><item><title>Type 1 Diabetes Mouse Model Expressing Human HLA-A2.1</title><caseId>M-ENGELHARD-MOUSEDVS</caseId><link>http://uva.technologypublisher.com/technology/8968</link><description>Reagent DescriptionThis model is useful for studying the role of MHC class I molecules in Type 1 Diabetes. The transgenic allele HLA-A2.1 from C57BL/6-Tg(HLA-A2.1)1Enge/J (stock# 3088) was backcrossed 10 generations to NOD/Lt prior to making the homozygote. Homozygous mice carrying the (HLA-A2.1)1Enge transgene ubiquitously express significant quantities of the human MHC class I HLA-A2.1 molecules. These HLA-A2.1 molecules mediate beta cell auto-reactive CD8 T cell responses that, when added to those elicited by endogenous murine MHC class I variants, result in a significantly accelerated rate...</description><pubDate>Wed, 07 Mar 2012 09:32:31 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8968</guid></item><item><title>Ubiquitin E2 T (UBE2T) Antibody</title><caseId>M-DUTTA-UBE2T</caseId><link>http://uva.technologypublisher.com/technology/8967</link><description><![CDATA[Production and Reactivity This rabbit polyclonal antibody was generated against amino acids 148&ndash;197 of human Ubiquitin-conjugating enzyme E2 T (UBE2T) and recognizes mouse and human homologs.ApplicationsWB, IPReferencesMol Cell. 2006 Aug;23(4):589-96. (Available online.)]]></description><pubDate>Wed, 07 Mar 2012 09:32:30 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8967</guid></item><item><title>Human Cdt1 (1-20) Antibody</title><caseId>M-DUTTA-NCDT1</caseId><link>http://uva.technologypublisher.com/technology/8966</link><description><![CDATA[Production and Reactivity This rabbit polyclonal antibody was generated against amino acids 1&ndash;20 of human replication factor Cdt1.ApplicationsWB, IPReferencesJ Biol Chem. 2006 Mar 10;281(10):6246-52. (Available online.)]]></description><pubDate>Wed, 07 Mar 2012 09:32:29 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8966</guid></item><item><title>Lin28 Antibody</title><caseId>M-DUTTA-LIN28</caseId><link>http://uva.technologypublisher.com/technology/8965</link><description>Production and Reactivity This rabbit polyclonal antibody was generated against human Lin28 and recognizes mouse and human homologs.ApplicationsWBReferencesJ Biol Chem. 2005 Apr 29;280(17):16635-41. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:32:29 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8965</guid></item><item><title>Human Geminin Antibody</title><caseId>M-DUTTA-GEMININ</caseId><link>http://uva.technologypublisher.com/technology/8964</link><description><![CDATA[Production and Reactivity This rabbit polyclonal antibody was generated against amino acids 1&ndash;209 of human Geminin.ApplicationsWB, IPReferencesScience. 2000 Dec 22;290(5500):2309-12. (Available online.)]]></description><pubDate>Wed, 07 Mar 2012 09:32:28 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8964</guid></item><item><title>Detection Method for Gene Translocation and DNA Fusion Junctions</title><caseId>M-DUTTA-CHROMPET</caseId><link>http://uva.technologypublisher.com/technology/8963</link><description>Executive SummaryResearchers at the University of Virginia have developed a method for high-throughput detection of disease-specific genomic rearrangements and have validated this method using chronic myeloid leukemia patient samples. This detection system can be utilized to provide clinical diagnosis, disease monitoring and treatment efficacy information.BackgroundChromosomal translocations, deletions and amplifications play a major role in many cancers. One such translocation is the Philadelphia chromosome, which has been linked to chronic myeloid leukemia (CML). In this case, the translocat...</description><pubDate>Wed, 07 Mar 2012 09:32:27 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8963</guid></item><item><title>Human Cdt1 (238-546) Antibody</title><caseId>M-DUTTA-CDT1</caseId><link>http://uva.technologypublisher.com/technology/8962</link><description><![CDATA[Production and Reactivity This rabbit polyclonal antibody was generated against amino acids 238&ndash;546 of human replication factor Cdt1.ApplicationsWB, IPReferencesScience. 2000 Dec 22;290(5500):2309-12. (Available online.)]]></description><pubDate>Wed, 07 Mar 2012 09:32:26 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8962</guid></item><item><title>Connexin 43 (CX43) flox Mouse Strain</title><caseId>M-DULING-CX43GEN</caseId><link>http://uva.technologypublisher.com/technology/8961</link><description>Reagent DescriptionMice homozygous for this CX43flox conditional allele are viable and fertile, with loxP sites flanking exon 2 of the targeted gene. Presence of the loxP sites has no reported effect on expression of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have exon 2 deleted in the Cre-expressing tissue(s). These CX43flox mutant mice may be useful in generating conditional mutations for studying the role of connexin and gap junctions in various tissues and systems, including the cardiovascular system.A full description can be found at th...</description><pubDate>Wed, 07 Mar 2012 09:32:25 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8961</guid></item><item><title>GST (Glutathione-S-Transferase) Antibody</title><caseId>M-DESIMONE-1C9AB</caseId><link>http://uva.technologypublisher.com/technology/8960</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG1 monoclonal antibody generated against GST and recognizes both native and denatured protein.Clone number:1C9-B4-A21C9-B4-A2Applications:WB, IP, ELISAReferences:J Cell Biol. 1996 Jul;134(1):227-40.Development. 1996 Sep;122(9):2873-83.]]></description><pubDate>Wed, 07 Mar 2012 09:32:25 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8960</guid></item><item><title>Gas Expanded Lubricants</title><caseId>M-CLARENS-GEL</caseId><link>http://uva.technologypublisher.com/technology/8959</link><description>Executive SummaryThis invention provides a method for lubricating bearings during operation in which mixtures of lubricant and high-pressure gas are supplied inside a reinforced casing. The gas serves to control the viscosity and thermal conductivity of the lubricant such that bearing characteristics, such as power loss, can be minimized as loading and speed conditions change.BackgroundWind turbines operate under a wide range of weather conditions that directly influence the temperature and loading on mechanical components. These natural variations have been shown to cause a large number of th...</description><pubDate>Wed, 07 Mar 2012 09:32:24 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8959</guid></item><item><title>RFID Object Localization System That Simultaneously Offers High Accuracy, Speed, Reliability</title><caseId>M-CHAWLA-RFID</caseId><link>http://uva.technologypublisher.com/technology/8958</link><description>Executive SummaryThe invention is an object localization system that leverages radio frequency identification (RFID) technology to provide a new, GPS-like positioning capability that simultaneously delivers high accuracy, speed and reliability not previously seen in RFID technologies. BackgroundRFID technology typically provides object tracking and identification functionality without providing object localization capabilities. Existing RFID-based localization techniques suffer from inherent position-estimate errors due to various factors (e.g., environmental interferences, radio frequency occ...</description><pubDate>Wed, 07 Mar 2012 09:32:23 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8958</guid></item><item><title>Targeted Treatment for the Inv(16) Subtype of Acute Myeloid Leukemia</title><caseId>M-BUSHWELLER-INV16</caseId><link>http://uva.technologypublisher.com/technology/8957</link><description><![CDATA[Executive SummaryUniversity of Virginia researchers have discovered novel compounds that can be used for the targeted treatment of the inv(16) subtype of Acute Myeloid Leukemia (AML), improving upon existing nonspecific chemotherapies. These compounds have the promise to vastly improve patients&rsquo; therapy tolerance, survival rates and relapse rates. BackgroundThe American Cancer Society estimates 12,810 new cases of AML and 9,000 AML-related deaths in 2009. AML sufferers face a five-year survival rate of only approximately 50 percent and a relapse rate of approximately 33 percent. Characte...]]></description><pubDate>Wed, 07 Mar 2012 09:32:22 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8957</guid></item><item><title>Thermally Responsive Composite Hydrogel</title><caseId>M-BUSH-HYDROGEL</caseId><link>http://uva.technologypublisher.com/technology/8956</link><description>Executive SummaryThe purpose of the invention is to produce a thermally sensitive hydrogel, which is a liquid at room temperature and solid at physiological temperature. The hydrogel can be injected at an injury site to deliver therapeutic agents. BackgroundThe products used currently in orthopedic surgery for delivery of protein are flimsy, collagen carriers that are little more than wet sponges. They provide little room for personalized medicine and the precise amount of protein delivered is difficult to quantitate. Chitosan thermogels used currently do not allow desirable tissue growth and ...</description><pubDate>Wed, 07 Mar 2012 09:32:21 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8956</guid></item><item><title>Oral General Anesthetics and Metabolically Resistant Anticonvulsants</title><caseId>M-BROWN-ANESTHESIA</caseId><link>http://uva.technologypublisher.com/technology/8955</link><description><![CDATA[Executive SummaryA researcher at the University of Virginia has discovered a group of novel compounds that have activity as anesthetics, anticonvulsants and neuroprotective agents. These compounds are unique in that they have been modified to prevent the formation of a common toxic metabolite.BackgroundThemisone has been widely utilized as an anticonvulsant since its discovery in the early 1950s. Despite the drug&rsquo;s substantial neuroprotective properties, themisone is known to suffer from the production of potentially harmful metabolites.&nbsp;&nbsp; About the InventionMilton L. Brown, M....]]></description><pubDate>Wed, 07 Mar 2012 09:32:21 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8955</guid></item><item><title>VP5 (HSV-1) Antibody</title><caseId>M-BROWN-AB6F10</caseId><link>http://uva.technologypublisher.com/technology/8954</link><description><![CDATA[Production and Reactivity:Mouse IgG1 monoclonal antibody generated against purified HSV-1B capsids and recognizes amino acids 862-880 of VP5, the major capsid protein.Clone number:6F10-D2-G2Applications:WB, IP, IFReferences:&nbsp;&nbsp;&nbsp; J Mol Biol. 1996 Nov 1;263(3):432-46.Virology. 1997 Feb 17;228(2):229-35.]]></description><pubDate>Wed, 07 Mar 2012 09:32:20 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8954</guid></item><item><title>p130/CAS Antibody</title><caseId>M-BOUTON-AB01</caseId><link>http://uva.technologypublisher.com/technology/8953</link><description><![CDATA[Production and Reactivity This mouse IgG2a antibody was generated against rat p130/CAS amino acids 576&ndash;796 and recognizes rat, mouse and human homologs.Clone number8G4ApplicationsWB, IP, IFReferencesHybridoma. 1997 Oct;16(5):403-11.]]></description><pubDate>Wed, 07 Mar 2012 09:32:19 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8953</guid></item><item><title>High-Presence, Low-Bandwidth, Apparent 3-D Video-Conferencing With a Single Camera</title><caseId>M-BOKER-FACE</caseId><link>http://uva.technologypublisher.com/technology/8952</link><description><![CDATA[


  
  
  
  
    Photo by Jackson 
  Smith


  
  
  
  
    Jeffrey R. Spies with (onscreen, left to right) Timothy R. 
      Brick and Steven M. Boker, Ph.D.&nbsp;
Executive SummaryUniversity of Virginia researchers have 
developed a novel method for enhancing users’ video-conferencing experience by 
enabling apparent three-dimensionality with the use of a single camera. 
High-presence and direct eye-contact conversations are achieved under 
low-bandwidth requirements without the need for expensive motion-capture 
technologies or multi-camera 
arrays.BackgroundVideo-conferencing has become...]]></description><pubDate>Wed, 07 Mar 2012 09:32:18 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8952</guid></item><item><title>Viscoelastic Silicone Rubber Devices and Related Methods</title><caseId>M-BLOOMFIELD-VISCO</caseId><link>http://uva.technologypublisher.com/technology/8951</link><description><![CDATA[BackgroundTraditional silicone rubbers are elastic polymers, or elastomers, which deform under the application of stress and regain their original shapes when the stress is removed. Silicone rubber&rsquo;s rigidity is not impacted by its time under stress; that is, silicone rubbers deform by the same magnitude whether subject to sudden impacts or prolonged stresses.Invention DescriptionLouis A. Bloomfield, Ph.D., at the University of Virginia has invented a broad class of viscoelastic silicone rubbers &mdash; including dense, foamed and comminuted materials &mdash; that respond differently und...]]></description><pubDate>Wed, 07 Mar 2012 09:32:17 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8951</guid></item><item><title>Human Serum Albumin (HSA) Antibody</title><caseId>M-BENJAMIN-HSA1</caseId><link>http://uva.technologypublisher.com/technology/8950</link><description>Production and Reactivity This mouse IgG1 monoclonal antibody was generated against human serum albumin (HSA), recognizes only HSA and does not react with chimpanzee, bovine, deer, dog, goat, gorilla, horse, orangutan, porcine, rabbit, rat, turkey, hamster, cat, raccoon, antelope, mule deer, elk, guinea pig, mouse or sheep homologs.Clone Number3B8-H3-G1ApplicationsWB, ELISAReferencesHybridoma. 1987 Apr;6(2):183-90.</description><pubDate>Wed, 07 Mar 2012 09:32:17 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8950</guid></item><item><title>K+ Channel and GPCR-Expressing HEK293 Cell Line</title><caseId>M-BAYLISS-CELL2</caseId><link>http://uva.technologypublisher.com/technology/8949</link><description>DescriptionThese HEK293 cells stably express GIRK1, GIRK4, TRH-R1 and 5-HT1A under G418 selection and exhibit G protein-coupled inwardly rectifying K  currents. The cell line is useful for the study of GIRK channel regulation.</description><pubDate>Wed, 07 Mar 2012 09:32:16 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8949</guid></item><item><title>K+  Channel-Expressing HEK293 Cell Line</title><caseId>M-BAYLISS-CELL</caseId><link>http://uva.technologypublisher.com/technology/8948</link><description>DescriptionThese HEK293 cells stably express GIRK1 and GIRK4 under G418 selection and exhibit G protein-coupled inwardly rectifying K  currents. The cell line is useful for the study of GIRK channel regulation.ReferencesProc Natl Acad Sci U S A. 2000 Aug 15;97(17):9771-6. (Available online.)</description><pubDate>Wed, 07 Mar 2012 09:32:15 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8948</guid></item><item><title>Self-Sensing Integrated System for Determining the Position of a Shaft in a Magnetic Bearing</title><caseId>M-ALLAIRE-SELF</caseId><link>http://uva.technologypublisher.com/technology/8946</link><description>Magnetic bearings levitate a rotating object (typically a rotor) with a magnetic field and are unstable in open-loop operation. Position feedback control is required to maintain the rotor in a centered position. Typically, a separate position sensor is used to directly measure the rotor's position for use in this feedback loop. Self-sensing magnetic bearings use the bearing's electrical signals to estimate rotor position.There are two primary classes of self-sensing methods: state estimation and inductance (displacement) measurement from switching Pulse Width Modulation (PWM) amplifier wavefor...</description><pubDate>Wed, 07 Mar 2012 09:32:14 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8946</guid></item><item><title>Hybrid 5-Axis Magnetic Bearing System</title><caseId>M-ALLAIRE-PASSIVE2</caseId><link>http://uva.technologypublisher.com/technology/8945</link><description>BackgroundMagnetic bearings are commonly used in many rotating machines, such as pumps, compressors and turbines. In such machines, a five-axis, active magnetic bearing configuration is frequently employed; this configuration must maintain power to electromagnets for each of the five axes. In this arrangement, one axial active magnetic thrust bearing acts upon a thrust disk that is attached to a rotor in order to control axial rotor vibrations, while two radial active magnetic bearings act upon the rotor in two directions to control radial vibrations. While this configuration is useful, it suf...</description><pubDate>Wed, 07 Mar 2012 09:32:13 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8945</guid></item><item><title>Frizzled Antibody</title><caseId>M-ADLER-ANTIFZ</caseId><link>http://uva.technologypublisher.com/technology/8944</link><description><![CDATA[Production and Reactivity:Mouse IgG1 monoclonal antibody generated against amino acids 1-252 of the D. melanogaster frizzled protein.Clone numbers:1C11-B9-H9-G9-D93A6-G11-H53G1-D4-G34B8-H1-B1Applications:WB, IFReferences:&nbsp;&nbsp;&nbsp; Mech Dev. 1994 Feb;45(2):127-37.]]></description><pubDate>Wed, 07 Mar 2012 09:32:12 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8944</guid></item><item><title>BMI-1/PSC Antibody</title><caseId>M-ADLER-ABPSC</caseId><link>http://uva.technologypublisher.com/technology/8943</link><description><![CDATA[Production and Reactivity:&nbsp; Mouse IgG2a 
monoclonal antibody generated against the homology region (HR, amino acids 
535-855) of D. melanogaster Posterior Sex Combs (PSC) and recognizes DmPSC and 
the mouse homolog, BMI-1.&nbsp; Due to the sequence homology across species the 
antibody is expected to cross react with many species.Clone 
numbers:1F4-E1-E26E8-E6-A8
Applications:WB, IP, 
IFReferences:&nbsp;&nbsp;&nbsp; Development. 1993 
Feb;117(2):641-55.]]></description><pubDate>Wed, 07 Mar 2012 09:32:11 GMT</pubDate><author>estabrook@virginia.edu</author><guid>http://uva.technologypublisher.com/technology/8943</guid></item></channel></rss>