Search Results - alexander+klibanov

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Multimodality Imaging Probe for Protein Critical to the Development of Arterial Obstructions, LOX-1 Executive SummaryThe invention is a multimodality imaging probe for detecting the oxidized LDL receptor, LOX-1. The researchers have successfully demonstrated LOX-1 staining using SPECT/CT, MRI and fluorescent imaging.BackgroundLOX-1 is a type II membrane protein with a short N-terminal cytoplasmic domain and a long C-terminal extracellular domain that... Published: 3/7/2012   |   Inventor(s): Alexander Klibanov, Dayuan Li, Amit Patel, Craig Meyer, George Beller, David Glover, Christopher Kramer Keywords(s):   Category(s): Recombinant Proteins and Peptides

Novel Atherosclerotic Plaque Detection/Assessment Technique for the Treatment of Heart Disease Courtesy Meyer Laboratory SPECT/CT imaging (A), phosphor imaging (B) and Sudan IV staining (C). All mice injected with LOX-1 probe had hotspots in the aortic arch (sagittal, coronal and transversal plane). Executive SummaryUniversity of Virginia researchers have developed a novel, non-invasive imaging technique... Published: 3/8/2012   |   Inventor(s): Alexander Klibanov, Dayuan Li, Amit Patel, Craig Meyer, George Beller, David Glover, Christopher Kramer Keywords(s): Imaging Category(s): Imaging & Radiology

New Platform for Targeted Intravascular Drug and Gene Delivery Executive SummaryThis novel device combines the imaging capabilities of intravascular ultrasound (IVUS) with the therapeutic effectiveness of targeted microbubbles. The result is a new paradigm for targeted drug and gene delivery that yields safer and more effective treatments. This device also enables treatment of diseases for which therapy is currently... Published: 3/8/2012   |   Inventor(s): John Hossack, Brian Wamhoff, Alexander Klibanov, Brent French, Johnny Chen Keywords(s): Devices, Medical Category(s): Medical Devices