Description:
Reagent Description
This model is useful for studying the role of MHC class I molecules in Type 1 Diabetes. The transgenic allele HLA-A2.1 from C57BL/6-Tg(HLA-A2.1)1Enge/J (stock# 3088) was backcrossed 10 generations to NOD/Lt prior to making the homozygote. Homozygous mice carrying the (HLA-A2.1)1Enge transgene ubiquitously express significant quantities of the human MHC class I HLA-A2.1 molecules. These HLA-A2.1 molecules mediate beta cell auto-reactive CD8 T cell responses that, when added to those elicited by endogenous murine MHC class I variants, result in a significantly accelerated rate of diabetes onset when compared to NOD/Lt controls.
A full description can be found at the Jackson Laboratory, where this strain is sold as stock number 005512. Use of this strain by companies or for-profit entities requires a license from the U.Va. Patent Foundation.
Strain Name
NOD.B6-Tg(HLA-A2.1)1Enge/DvsJ
References
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13753-8. (Available online.)
