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Human Mast Cell Line Ideal for Inflammation Studies
Executive SummaryThis technology is an immortalized human mast cell line that is easily cultured without growth factors and that has a high expression of FcεRI for investigating inflammation response.BackgroundMast cells exist in several types of tissues and play a role in allergy and anaphylaxis as a factor in inflammation response. They are...
Published: 3/7/2012
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Inventor(s): John Steinke, Larry Borish, Brandon Early
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Category(s): Cell Lines
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Adenosine Receptor-Expressing HEK293 and CHO-K1 Cell Lines
DescriptionThese HEK293 and CHO-K1 cells stably express all four types of human adenosine receptors. Membranes prepared from these cells can be used to screen compounds to determine their affinities for human adenosine receptors. U.S. patent 5,854,081 has been issued on this technology.ReferencesBiochem Pharmacol. 1996 Feb 23;51(4):545-55. (Available...
Published: 3/7/2012
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Inventor(s): Joel Linden, Heidi Taylor, Anna Robeva, Robin Woodard, Xiaowei Jin
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Category(s): Cell Lines
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K+ Channel and GPCR-Expressing HEK293 Cell Line
DescriptionThese HEK293 cells stably express GIRK1, GIRK4, TRH-R1 and 5-HT1A under G418 selection and exhibit G protein-coupled inwardly rectifying K currents. The cell line is useful for the study of GIRK channel regulation.
Published: 3/7/2012
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Inventor(s): Douglas Bayliss
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Category(s): Cell Lines
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K+ Channel-Expressing HEK293 Cell Line
DescriptionThese HEK293 cells stably express GIRK1 and GIRK4 under G418 selection and exhibit G protein-coupled inwardly rectifying K currents. The cell line is useful for the study of GIRK channel regulation.ReferencesProc Natl Acad Sci U S A. 2000 Aug 15;97(17):9771-6. (Available online.)
Published: 3/7/2012
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Inventor(s): Douglas Bayliss
Keywords(s):
Category(s): Cell Lines
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