Neutrophil-Specific, NIR Fluorescent Imaging Agent
Case ID:
M-PAN-CY7PEPTIDE
Description:
| Courtesy of Pan, Zhang,
Xiao |
| This figure shows NIR fluorescence
image three hours after injection of cFLFLF-PEG76-Cy7 in a mouse model of
ear inflammation. (A) shows probe accumulation in the PMA-treated ear. (B)
shows probe specificity shown by pre-injection with a non-fluorescence
peptide. |
Reagent Description
This reagent is a Cy7-conjugated,
PEG-modified hexapeptide that specifically binds the formyl peptide receptor
(FPR) of neutrophils. After tail vein injection of the agent, sites of
inflammation, where neutrophils have been recruited and activated, can be imaged
in vivo by near-infrared (NIR)
fluorescence.
References
Bioorg Med Chem Lett. 2010
Jun 15;20(12):3515-7. (Available online.)
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